Octreotide acetate, the active pharmaceutical ingredient in the long‐acting release (LAR) drug product Sandostatin®, is a cyclic octapeptide that mimics the naturally occurring somatostatin peptide hormone. Modern NMR can be a robust analytical method to identify and quantify octreotide molecules. Previous1H chemical shift assignments were mostly performed in organic solvents, and no assignments for heteronuclear13C,15N, and aromatic1H nuclei are available. Here, using state‐of‐the‐art 1D and 2D homo‐ and heteronuclear NMR experiments, octreotide was fully assigned, including water exchangeable amide protons, in aqueous buffer except for13CO and15NH of F1,15NH of C2, and15N
Cannabicitran is an important cannabinoid natural product produced by
- Award ID(s):
- 2116395
- NSF-PAR ID:
- 10361789
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Magnetic Resonance in Chemistry
- Volume:
- 60
- Issue:
- 2
- ISSN:
- 0749-1581
- Page Range / eLocation ID:
- p. 196-202
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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