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Title: Self-assembled Nucleic Acid Nanostructures for Biomedical Applications
Abstract: Structural DNA nanotechnology has been developed into a powerful method for creating self-assembled nanomaterials. Their compatibility with biosystems, nanoscale addressability, and programmable dynamic features make them appealing candidates for biomedical research. This review paper focuses on DNA self-assembly strategies and designer nanostructures with custom functions for biomedical applications. Specifically, we review the development of DNA self-assembly methods, from simple DNA motifs consisting of a few DNA strands to complex DNA architectures assembled by DNA origami. Three advantages are discussed using structural DNA nanotechnology for biomedical applications: (1) precise spatial control, (2) molding and guiding other biomolecules, and (3) using reconfigurable DNA nanodevices to overcome biomedical challenges. Finally, we discuss the challenges and opportunities of employing DNA nanotechnology for biomedical applications, emphasizing diverse assembly strategies to create a custom DNA nanostructure with desired functions.  more » « less
Award ID(s):
2046835 2007821
PAR ID:
10388529
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Current Topics in Medicinal Chemistry
Volume:
22
Issue:
8
ISSN:
1568-0266
Page Range / eLocation ID:
652 to 667
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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