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Title: Ultra‐Flexible Giant Magnetoresistance Biosensors for Lab‐on‐a‐Needle Biosensing
Abstract

Flexible biosensors exhibit great potential for the detection of various biomarkers with the ability to adapt to different surface textures. Here, a lab‐on‐a‐needle biosensing platform based on ultra‐flexible giant magnetoresistance (GMR) biosensors is developed. The fabricated flexible GMR sensors exhibit a MR ratio of 5.2% and a sensitivity of 0.13%/Oe in the linear region, which are comparable to their rigid counterparts. It is found that the magnetic properties of the flexible GMR sensors remain unchanged after 500 cycles of compressive and tensile stress, indicating strong robustness even when applied to a surface that is constantly in motion. The developed platform is then employed for the detection of different concentrations of canine osteosarcoma (OSCA‐8) cells with a limit of detection (LOD) of 200 cells in 20 µL sample (104cells per mL), which demonstrate the ability to perform real‐time, sensitive, and quantitative cell detection.

 
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Award ID(s):
2011401
NSF-PAR ID:
10391100
Author(s) / Creator(s):
 ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  
Publisher / Repository:
Wiley Blackwell (John Wiley & Sons)
Date Published:
Journal Name:
Advanced Materials Interfaces
Volume:
10
Issue:
7
ISSN:
2196-7350
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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