Alternative polyadenylation (APA) regulates diverse developmental and physiological processes through its effects on gene expression, mRNA stability, translatability, and transport.
- Award ID(s):
- 2150087
- NSF-PAR ID:
- 10395426
- Editor(s):
- Sindhu Sareen
- Date Published:
- Journal Name:
- Frontiers of plant science
- Volume:
- 13
- ISSN:
- 0016-2167
- Page Range / eLocation ID:
- 965530.
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Summary Sorghum is a major cereal crop in the world and, despite its importance, not much is known about the role of post‐transcriptional regulation in mediating responses to abiotic stresses inSorghum . A genome‐wide APA analysis unveiled widespread occurrence of APA inSorghum in response to drought, heat, and salt stress. Abiotic stress treatments incited changes in poly(A) site choice in a large number of genes. Interestingly, abiotic stresses led to the re‐directing of transcriptional output into non‐productive pathways defined by the class of poly(A) site utilized. This result revealed APA to be part of a larger global response ofSorghum to abiotic stresses that involves the re‐direction of transcriptional output into non‐productive transcriptional and translational pathways. Large numbers of stress‐inducible poly(A) sites could not be linked with known, annotated genes, suggestive of the existence of numerous unidentified genes whose expression is strongly regulated by abiotic stresses. Furthermore, we uncovered a novel stress‐specificcis ‐element in intronic poly(A) sites used in drought‐ and heat‐stressed plants that might play an important role in non‐canonical poly(A) site choice in response to abiotic stresses. -
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.3389/fpls.2022.965530
