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1. Effects of nutrient depletion on tissue growth in a tissue engineering scaffold pore

   https://doi.org/10.1063/5.0071171  

   Zong, Zeshun; Li, Xinyu; Sanaei, Pejman (December 2021, Physics of Fluids)
2. A multi‐tissue view on telomere dynamics and postnatal growth

   https://doi.org/10.1002/jez.2571  

   Wolf, Sarah E.; Rosvall, Kimberly A. (April 2022, Journal of Experimental Zoology Part A: Ecological and Integrative Physiology)
3. Effects of cell packing on chemoattractant distribution within a tissue

   https://doi.org/10.3934/biophy.2018.1.1  

   Mekus, Zachary; Cooley, Jessica; George, Aaron; Sabo, Victoria; Strzegowski, Morgan; Starz-Gaiano, Michelle; E. Peercy, Bradford (January 2018, AIMS Biophysics)
4. Microengineering of a Three-Dimensional Heart on Chip Tissue Model

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5. Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff

   https://doi.org/10.1186/s12915-022-01328-w  

   Gupta, Vanika; Frank, Ashley M.; Matolka, Nick; Lazzaro, Brian P. (December 2022, BMC Biology)

   Abstract Background Single tissues can have multiple functions, which can result in constraints, impaired function, and tradeoffs. The insect fat body performs remarkably diverse functions including metabolic control, reproductive provisioning, and systemic immune responses. How polyfunctional tissues simultaneously execute multiple distinct physiological functions is generally unknown. Immunity and reproduction are observed to trade off in many organisms but the mechanistic basis for this tradeoff is also typically not known. Here we investigate constraints and trade-offs in the polyfunctional insect fat body. Results Using single-nucleus sequencing, we determined that the Drosophila melanogaster fat body executes diverse basal functions with heterogenous cellular subpopulations. The size and identity of these subpopulations are remarkably stable between virgin and mated flies, as well as before and after infection. However, as an emergency function, the immune response engages the entire tissue and all cellular subpopulations produce induce expression of defense genes. We found that reproductively active females who were given bacterial infection exhibited signatures of ER stress and impaired capacity to synthesize new protein in response to infection, including decreased capacity to produce antimicrobial peptides. Transient provision of a reversible translation inhibitor to mated females prior to infection rescued general protein synthesis, specific production of antimicrobial peptides, and survival of infection. Conclusions The commonly observed tradeoff between reproduction and immunity appears to be driven, in D. melanogaster , by a failure of the fat body to be able to handle simultaneous protein translation demands of reproductive provisioning and immune defense. We suggest that inherent cellular limitations in tissues that perform multiple functions may provide a general explanation for the wide prevalence of physiological and evolutionary tradeoffs. 

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