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Title: Nickel-catalyzed arylative substitution of homoallylic alcohols
Direct coupling of unactivated alcohols remains a challenge in synthetic chemistry. Current approaches to cross-coupling of alcohol-derived electrophiles often involve activated alcohols such as tosylates or carbonates. We report the direct arylative substitution of homoallylic alcohols catalyzed by a nickel-bisphosphine complex as a facile method to generate allylic arenes. These reactions proceed via formation of an allylic alcohol intermediate. Subsequent allylic substitution with arylboroxine nucleophiles enables the formation of a variety of allylic arenes. The presence of p -methoxyphenylboronic acid is crucial to activate the allylic alcohol to achieve high product yields.  more » « less
Award ID(s):
1955529
NSF-PAR ID:
10400434
Author(s) / Creator(s):
; ; ; ;
Date Published:
Journal Name:
Chemical Science
Volume:
13
Issue:
39
ISSN:
2041-6520
Page Range / eLocation ID:
11607 to 11613
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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