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1. Gas-Assisted Cocrystal Desublimation

   https://doi.org/10.1021/acs.cgd.1c01241  

   Sanvordenker, Shea; Borsadia, Siddharth; Morris, Steve; Rodríguez-Hornedo, Naír; Shtein, Max (March 2022, Crystal Growth & Design)
2. Phototriggered Guest Release from a Nonporous Organic Crystal: Remarkable Single-Crystal-to-Single-Crystal Transformation of a Binary Cocrystal Solvate to a Ternary Cocrystal

   https://doi.org/10.1021/jacs.0c09732  

   Yelgaonkar, Shweta P.; Campillo-Alvarado, Gonzalo; MacGillivray, Leonard R. (December 2020, Journal of the American Chemical Society)

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3. Solid Decolorization: Dismantling of an Orange‐Red Zwitterionic Cocrystal by Multicomponent Milling

   https://doi.org/10.1002/adom.202400889  

   Ezekiel, Charles_Izuchukwu; Ortiz‐de_León, Celymar; Reinheimer, Eric; MacGillivray, Leonard_R (May 2024, Advanced Optical Materials)

   Abstract An application of multi‐component milling is described to achieve a decolorization by dismantling the orange‐red zwitterionic cocrystal (PDA)∙(APAP) (wherePDA= 2,4‐pyridinedicarboxylic acid,APAP= acetaminophen) usingn,n′‐BPE(BPE=trans‐1,2‐bis(n‐pyridylethylene and forn=n′ = 3 or 4). Each ofn,n′‐BPEforms a colorless hydrogen‐bonded cocrystal withPDA. 

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4. Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

   https://doi.org/10.1126/sciadv.1600001  

   Nicklisch, Sascha C.; Rees, Steven D.; McGrath, Aaron P.; Gökirmak, Tufan; Bonito, Lindsay T.; Vermeer, Lydia M.; Cregger, Cristina; Loewen, Greg; Sandin, Stuart; Chang, Geoffrey; et al (April 2016, Science Advances)

   The world’s oceans are a global reservoir of persistent organic pollutants to which humans and other animals are exposed. Although it is well known that these pollutants are potentially hazardous to human and environmental health, their impacts remain incompletely understood. We examined how persistent organic pollutants interact with the drug efflux transporter P-glycoprotein (P-gp), an evolutionarily conserved defense protein that is essential for protection against environmental toxicants. We identified specific congeners of organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers that inhibit mouse and human P-gp, and determined their environmental levels in yellowfin tuna from the Gulf of Mexico. In addition, we solved the cocrystal structure of P-gp bound to one of these inhibitory pollutants, PBDE (polybrominated diphenyl ether)–100, providing the first view of pollutant binding to a drug transporter. The results demonstrate the potential for specific binding and inhibition of mammalian P-gp by ubiquitous congeners of persistent organic pollutants present in fish and other foods, and argue for further consideration of transporter inhibition in the assessment of the risk of exposure to these chemicals. 

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5. Generating Cocrystal Polymorphs with Information Entropy Driven by Molecular Dynamics-Based Enhanced Sampling

   https://doi.org/10.1021/acs.jpclett.0c02647  

   Song, Hongxing; Vogt-Maranto, Leslie; Wiscons, Ren; Matzger, Adam J.; Tuckerman, Mark E. (November 2020, The Journal of Physical Chemistry Letters)

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