A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.
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Carboxylic‐Phosphoric Anhydrides as Direct Electrophiles for Decarbonylative Hirao Cross‐Coupling of Carboxylic Acids: DFT Investigation of Mechanistic Pathway
- Award ID(s):
- 1650766
- PAR ID:
- 10412459
- Date Published:
- Journal Name:
- Chemistry – An Asian Journal
- Volume:
- 18
- Issue:
- 7
- ISSN:
- 1861-4728
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation