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Title: Electrochemical borylation of carboxylic acids
A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.  more » « less
Award ID(s):
2002158
PAR ID:
10322736
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Proceedings of the National Academy of Sciences
Volume:
118
Issue:
34
ISSN:
0027-8424
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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