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Title: Orthogonal Supramolecular Assemblies Using Side-Chain Functionalized Helical Poly(isocyanide)s
Mimicking the structure of proteins using synthetic polymers requires building blocks with structural similarity and the use of various noncovalent and dynamic covalent interactions. We report the synthesis of helical poly(isocyanide)s bearing diaminopyridine and pyridine side-chains and the multistep functionalization of the polymers’ side-chains using hydrogen-bonding and metal-coordination. The orthogonality of the hydrogen-bonding and metal-coordination was proved by varying the sequence of the multistep assembly. The two side-chain functionalization are reversible through the use of competitive solvents and/or competing ligands. Throughout the assembly and disassembly, the helical conformation of the polymer backbone is sustained as proved by circular dichroism spectroscopy. These results open the possibility to incorporate helical domains into complex polymer architectures and create a helical scaffold for smart materials.  more » « less
Award ID(s):
2203929
PAR ID:
10413341
Author(s) / Creator(s):
; ;
Date Published:
Journal Name:
Macromolecules
ISSN:
0024-9297
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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