Abstract The ability to predict individualized treatment effects (ITEs) based on a given patient's profile is essential for personalized medicine. We propose a hypothesis testing approach to choosing between two potential treatments for a given individual in the framework of high-dimensional linear models. The methodological novelty lies in the construction of a debiased estimator of the ITE and establishment of its asymptotic normality uniformly for an arbitrary future high-dimensional observation, while the existing methods can only handle certain specific forms of observations. We introduce a testing procedure with the type I error controlled and establish its asymptotic power. The proposed method can be extended to making inference for general linear contrasts, including both the average treatment effect and outcome prediction. We introduce the optimality framework for hypothesis testing from both the minimaxity and adaptivity perspectives and establish the optimality of the proposed procedure. An extension to high-dimensional approximate linear models is also considered. The finite sample performance of the procedure is demonstrated in simulation studies and further illustrated through an analysis of electronic health records data from patients with rheumatoid arthritis.
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Persuasion with Precision: Using Natural Language Processing to Improve Instrument Fidelity for Risk Communication Experimental Treatments
Instrument fidelity in message testing research hinges upon how precisely messages operationalize treatment conditions. However, numerous message testing studies have unmitigated threats to validity and reliability because no established procedures exist to guide construction of message treatments. Their construction typically occurs in a black box, resulting in suspect inferential conclusions about treatment effects. Because a mixed methods approach is needed to enhance instrument fidelity in message testing research, this article contributes to the field of mixed methods research by presenting an integrated multistage procedure for constructing precise message treatments using an exploratory sequential mixed methods design. This work harnesses the power of integration through crossover analysis to improve instrument fidelity in message testing research through the use of natural language processing (NLP).
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- Award ID(s):
- 1757351
- PAR ID:
- 10413749
- Date Published:
- Journal Name:
- Journal of Mixed Methods Research
- ISSN:
- 1558-6898
- Page Range / eLocation ID:
- 155868982210969
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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