Nimorazole belongs to the imidazole‐based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We envision the use of [15N3]nimorazole as a theragnostic hypoxia contrast agent that can be potentially deployed in the next‐generation MRI‐LINAC systems. Herein, we report the first steps to create long‐lasting (for tens of minutes) hyperpolarized state on three15N sites of [15N3]nimorazole with T1of up to ca. 6 minutes. The nuclear spin polarization was boosted by ca. 67000‐fold at 1.4 T (corresponding to
This content will become publicly available on February 1, 2024
- NSF-PAR ID:
- 10419708
- Date Published:
- Journal Name:
- Molecules
- Volume:
- 28
- Issue:
- 3
- ISSN:
- 1420-3049
- Page Range / eLocation ID:
- 1198
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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