Multicompartmental responsive microstructures with the capability for the pre‐programmed sequential release of multiple target molecules of opposite solubility (hydrophobic and hydrophilic) in a controlled manner have been fabricated. Star block copolymers with dual‐responsive blocks (temperature for poly(
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Poly(Piloty's acid): a slow releasing macromolecular HNO donor
We report a polymeric version of Piloty's acid where the release rate of HNO can be tuned by changing the block ratios of PEG- b -poly(Piloty's acid) in a block copolymer system. The poly(Piloty's acid) block was derived from poly(styrene sulfonate), and HNO release from the block copolymers varied by as much as an order of magnitude via increasing the length of the poly(Piloty's acid) block. We anticipate this study will guide the development of HNO-releasing polymers to measure the effects of sustained HNO delivery in biological systems.
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- Award ID(s):
- 2003662
- NSF-PAR ID:
- 10420126
- Date Published:
- Journal Name:
- Polymer Chemistry
- Volume:
- 14
- Issue:
- 21
- ISSN:
- 1759-9954
- Page Range / eLocation ID:
- 2572 to 2576
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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