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Title: Single-Micelle-Templated Synthesis of Hollow Barium Carbonate Nanoparticle for Drug Delivery
A laboratory-synthesized triblock copolymer poly(ethylene oxide-b-acrylic acid-b-styrene) (PEG-PAA-PS) was used as a template to synthesize hollow BaCO3 nanoparticles (BC-NPs). The triblock copolymer was synthesized using reversible addition–fragmentation chain transfer radical polymerization. The triblock copolymer has a molecular weight of 1.88 × 104 g/mol. Transmission electron microscopy measurements confirm the formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution. Furthermore, the dynamic light scattering experiment revealed the electrostatic interaction of Ba2+ ions with an anionic poly(acrylic acid) block of the micelles. The controlled precipitation of BaCO3 around spherical polymeric micelles followed by calcination allows for the synthesis of hollow BC-NPs with cavity diameters of 15 nm and a shell thickness of 5 nm. The encapsulation and release of methotrexate from hollow BC-NPs at pH 7.4 was studied. The cell viability experiments indicate the possibility of BC-NPs maintaining biocompatibility for a prolonged time.  more » « less
Award ID(s):
2100710
PAR ID:
10436966
Author(s) / Creator(s):
; ; ; ; ;
Date Published:
Journal Name:
Polymers
Volume:
15
Issue:
7
ISSN:
2073-4360
Page Range / eLocation ID:
1739
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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