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Title: An Fe complex for 19 F magnetic resonance-based reversible redox sensing and multicolor imaging
We report a first-in-class responsive, pentafluorosulfanyl (–SF 5 )-tagged 19 F MRI agent capable of reversibly detecting reducing environments via an Fe II/III redox couple. In the Fe III form, the agent displays no 19 F MR signal due to paramagnetic relaxation enhancement-induced signal broadening; however, upon rapid reduction to Fe II with one equivalent of cysteine, the agent displays a robust 19 F signal. Successive oxidation and reduction studies validate the reversibility of the agent. The –SF 5 tag in this agent enables ‘multicolor imaging’ in conjunction with sensors containing alternative fluorinated tags and this was demonstrated via simultaneous monitoring of the 19 F MR signal of this –SF 5 agent and a hypoxia-responsive agent containing a –CF 3 group.  more » « less
Award ID(s):
1945401
PAR ID:
10421637
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Chemical Science
Volume:
14
Issue:
19
ISSN:
2041-6520
Page Range / eLocation ID:
5099 to 5105
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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