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Title: Enhancing the Depth of Analyses with Next-Generation Ion Mobility Experiments
Recent developments in ion mobility (IM) technology have expanded the capability to separate and characterize gas-phase ions of biomolecules, especially when paired with mass spectrometry. This next generation of IM technology has been ushered in by creative innovation focused on both instrument architectures and how electric fields are applied. In this review, we focus on the application of high-resolution and multidimensional IM to biomolecular analyses, encompassing the fields of glycomics, lipidomics, peptidomics, and proteomics. We highlight selected research that demonstrates the application of the new IM toolkit to challenging biomolecular systems. Through our review of recently published literature, we outline the current strengths of respective technologies and perspectives for future applications.  more » « less
Award ID(s):
2203513
PAR ID:
10423670
Author(s) / Creator(s):
; ; ;
Date Published:
Journal Name:
Annual Review of Analytical Chemistry
Volume:
16
Issue:
1
ISSN:
1936-1327
Page Range / eLocation ID:
27 to 48
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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