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ABSTRACT Staphylococcus aureus is a leading cause of a wide range of clinical infections. Here, we announce the complete genome sequence of S. aureus siphophage Lorac, a phiETA-like temperate phage that is similar at the nucleotide level to the previously described S. aureus prophage phiNM2.
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Potent pan-group quorum sensing inhibitors in Staphylococcus aureus revealed by N-terminal tailoring of peptidomimetics
Staphylococcus aureus uses small peptides to assess its population densisty ( i.e. , quorum sensing) and regulate virulence at high cell number. Here, we report the design and synthesis of peptidomimetics based on these native signals that strongly block this communication pathway in all four specificity groups of S. aureus .
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- Award ID(s):
- 2108511
- PAR ID:
- 10432625
- Date Published:
- Journal Name:
- Chemical Communications
- Volume:
- 59
- Issue:
- 5
- ISSN:
- 1359-7345
- Page Range / eLocation ID:
- 587 to 590
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1039/D2CC05733F
