skip to main content

Attention:

The NSF Public Access Repository (NSF-PAR) system and access will be unavailable from 11:00 PM ET on Friday, September 13 until 2:00 AM ET on Saturday, September 14 due to maintenance. We apologize for the inconvenience.


Title: Pathway of transient electronics towards connected biomedical applications
Transient electronic devices have shown promising applications in hardware security and medical implants with diagnosing therapeutics capabilities since their inception. Control of the device transience allows the device to “dissolve at will” after its functional operation, leading to the development of on-demand transient electronics. This review discusses the recent developments and advantages of triggering strategies ( e.g. , electrical, thermal, ultrasound, and optical) for controlling the degradation of on-demand transient electronics. We also summarize bioresorbable sensors for medical diagnoses, including representative applications in electrophysiology and neurochemical sensing. Along with the profound advancements in medical diagnosis, the commencement of therapeutic systems such as electrical stimulation and drug delivery for the biomedical or medical implant community has also been discussed. However, implementing a transient electronic system in real healthcare infrastructure is still in its infancy. Many critical challenges still need to be addressed, including strategies to decouple multimodal sensing signals, dissolution selectivity in the presence of multiple stimuli, and a complete sensing–stimulation closed-loop system. Therefore, the review discusses future opportunities in transient decoupling sensors and robust transient devices, which are selective to a particular stimulus and act as hardware-based passwords. Recent advancements in closed-loop controller-enabled electronics have also been analyzed for future opportunities of using data-driven artificial intelligence-powered controllers in fully closed-loop transient systems.  more » « less
Award ID(s):
1933072
NSF-PAR ID:
10433235
Author(s) / Creator(s):
;
Date Published:
Journal Name:
Nanoscale
Volume:
15
Issue:
9
ISSN:
2040-3364
Page Range / eLocation ID:
4236 to 4249
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
More Like this
  1. Real-time monitoring of the gastrointestinal tract in a safe and comfortable manner is valuable for the diagnosis and therapy of many diseases. Within this realm, our review captures the trends in ingestible capsule systems with a focus on hardware and software technologies used for capsule endoscopy and remote patient monitoring. We introduce the structure and functions of the gastrointestinal tract, and the FDA guidelines for ingestible wireless telemetric medical devices. We survey the advanced features incorporated in ingestible capsule systems, such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging with adaptive frame rates, and rapid reading software. Examples of experimental and commercialized capsule systems are presented with descriptions of their sensors, devices, and circuits for gastrointestinal health monitoring. We also show the recent research in biocompatible materials and batteries, edible electronics, and alternative energy sources for ingestible capsule systems. The results from clinical studies are discussed for the assessment of key performance indicators related to the safety and effectiveness of ingestible capsule procedures. Lastly, the present challenges and outlook are summarized with respect to the risks to health, clinical testing and approval process, and technology adoption by patients and clinicians. 
    more » « less
  2. Abstract

    The practical applications of skin‐interfaced sensors and devices in daily life hinge on the rational design of surface wettability to maintain device integrity and achieve improved sensing performance under complex hydrated conditions. Various bioinspired strategies have been implemented to engineer desired surface wettability for varying hydrated conditions. Although the bodily fluids can negatively affect the device performance, they also provide a rich reservoir of health‐relevant information and sustained energy for next‐generation stretchable self‐powered devices. As a result, the design and manipulation of the surface wettability are critical to effectively control the liquid behavior on the device surface for enhanced performance. The sensors and devices with engineered surface wettability can collect and analyze health biomarkers while being minimally affected by bodily fluids or ambient humid environments. The energy harvesters also benefit from surface wettability design to achieve enhanced performance for powering on‐body electronics. This review first summarizes the commonly used approaches to tune the surface wettability for target applications toward skin‐interfaced sensors and devices. By considering the existing challenges, one also discusses the opportunities as a small fraction of potential future developments, which can lead to a new class of skin‐interfaced devices for use in digital health and personalized medicine.

     
    more » « less
  3. Abstract

    The growing demand for energy in wearable sensors and portable electronics necessitates the development of self‐contained, sustainable, and mobile power sources capable of harvesting environmental energies. Researchers have made significant strides in implementing photovoltaics, thermoelectrics, piezoelectrics, and triboelectrics in 2D materials. This has resulted in significant advancements in wearable energy harvesting systems based on 2D materials. This review discusses the relationship between synthesis procedures, material structures/properties, and device performance in the context of 2D materials‐based wearable energy harvesting technologies. Finally, challenges and future research opportunities are identified and discussed based on current progress.

     
    more » « less
  4. Abstract

    Recent advances in soft sensors and flexible electronics offer various applications in detecting physical, electrical, and chemical signals. However, there are still technical barriers in current mechanical, electrical, and material properties for enhanced signal sensing. When measuring signals from the human skin, minimizing the skin‐sensor contact impedance is still challenging while maximizing sensitivity through optimized materials and soft electronics. Here, this review summarizes recent advances in materials, manufacturing, and integration technologies to develop ultrathin soft sensors for monitoring various human physiological signals. The enhancements in soft and compliant structures and mechanical properties are critical to making reliable wearable electronic systems. This article shares the details of soft sensors, integration processes, manufacturing methods, and their applications to target physical, electrical, and chemical signals. In addition, the limitations and current trends in developing multifunctional sensors, self‐powered devices, and integration with external stimuli systems are discussed.

     
    more » « less
  5.  
    more » « less