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1. The Impact of Sleep Disturbance on Regional Brain Volumes

   https://doi.org/10.1093/geroni/igaa057.1521  

   Burke, Shanna; Li, Tan; Grudzien, Adrienne; Barnes, Christopher; Hanson, Kevin; DeKosky, Steven (December 2020, Innovation in Aging)

   null (Ed.)

   Abstract Sleep disruption has been associated with increased beta-amyloid deposition and greater risk for later development of Alzheimer’s disease. Studies indicate that sleep disturbance correlates with regional brain volumes, but data are limited. We sought to determine the effect of sleep disturbance on regional brain volumes by cognitive and apolipoprotein e (APOE) e4 status. We conducted a secondary analysis of the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set using complete structural imaging data from 1,371 participants (mean age: 70.5; SD: 11.7). Multiple linear regression was used to estimate the adjusted effect of sleep disturbance (via Neuropsychiatric Inventory Questionnaire) on regional brain volumes through measurement of 30 structural MRI biomarkers. Sleep disruption was associated with greater volumes in the right and left lateral ventricles and greater volume of total white matter hyperintensities (p<.05). Lower mean volumes in total brain, total gray matter, and total cerebrum grey matter volumes, and in 12 hippocampal, frontal, parietal, and temporal lobe volumes were observed among participants who reported sleep disturbance. Males, Hispanic participants, and those with less education were more likely to report sleep disruption. Cognitive status moderated the relationship between sleep disturbance and lateral ventricular volumes, while APOE e4 moderated the effect between sleep disturbance and parietal lobe volumes. These findings suggest that disrupted sleep is associated with atrophy across multiple brain regions and ventricular hydrocephalus ex vacuo, after controlling for intracranial volume and demographic covariates. The influence of cognition and APOE e4 status indicates that this relationship is affected by co-occurring physiological processes. 

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2. Social Identity, Social Media Use, and Mental Health in Adults: Investigating the Mediating Role of Cyberbullying Experiences and the Moderating Effects of Gender and Age

   https://doi.org/10.2147/PRBM.S466965  

   Barragan, Natali; Batista, Amanda; Hall, Deborah; Silva, Yasin (November 2024, Psychology Research and Behavior Management)

   Purpose: Previous research points to a complex relation between social media use and mental health, with open questions remaining with respect to mediation pathways and potential sociodemographic moderators. The present research investigated the extent to which experiences of cyberbullying victimization mediate the link between greater social media use and poorer mental health in adults and whether such indirect effects are moderated by gender or age. Participants and methods: As part of a larger study, US adults (N = 502) completed an online survey that included measures of degree of social media use, cyberbullying victimization, depression, anxiety, substance use, and sociodemographic characteristics including gender and age. Results: A series of moderated mediation models revealed a robust indirect effect of cyberbullying victimization on the relation between degree of social media use and mental health, such that greater social media use was associated with higher levels of cyberbullying victimization and greater cyberbullying victimization was associated with increased depression, anxiety, and likelihood of substance use. There was no evidence that the mediation effects varied between men and women. Age did, however, moderate the mediation effects for anxiety and likelihood of substance use, with stronger mediation effects emerging for younger compared to older adults. Conclusion: Our findings underscore the importance of empirical investigations that shed a more nuanced light on the complex relation between social media and mental health. 

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3. Habitual sleep is associated with both source memory and hippocampal subfield volume during early childhood

   https://doi.org/10.1038/s41598-020-72231-z  

   Riggins, Tracy; Spencer, Rebecca M. C. (September 2020, Scientific Reports)

   Abstract Previous research has established important developmental changes in sleep and memory during early childhood. These changes have been linked separately to brain development, yet few studies have explored their interrelations during this developmental period. The goal of this report was to explore these associations in 200 (100 female) typically developing 4- to 8-year-old children. We examined whether habitual sleep patterns (24-h sleep duration, nap status) were related to children’s performance on a source memory task and hippocampal subfield volumes. Results revealed that, across all participants, after controlling for age, habitual sleep duration was positively related to source memory performance. In addition, in younger (4–6 years, n = 67), but not older (6–8 years, n = 70) children, habitual sleep duration was related to hippocampal head subfield volume (CA2-4/DG). Moreover, within younger children, volume of hippocampal subfields varied as a function of nap status; children who were still napping (n = 28) had larger CA1 volumes in the body compared to children who had transitioned out of napping (n = 39). Together, these findings are consistent with the hypothesis that habitually napping children may have more immature cognitive networks, as indexed by hippocampal integrity. Furthermore, these results shed additional light on why sleep is important during early childhood, a period of substantial brain development. 

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4. Discrimination and Cardiovascular Health in Black Americans: Exploring Inflammation as a Mechanism and Perceived Control as a Protective Factor

   https://doi.org/10.1097/PSY.0000000000001300  

   Merritt, Carrington C; Muscatell, Keely A (April 2024, Psychosomatic Medicine)

   ABSTRACT ObjectiveInflammation may be an integral physiological mechanism through which discrimination impacts cardiovascular health and contributes to racial health disparities. Limited research has examined psychosocial factors that protect against the negative effects of discrimination on inflammation. Perceived control is a promising possible protective factor, given that it has been shown to moderate the relationship between other psychosocial stressors and physiological outcomes. This study thus tested whether systemic inflammation mediated the link between discrimination and cardiovascular health and whether perceived control moderated this relationship. MethodsData for this project included 347 non-Hispanic/Latinx Black adults (mean [standard deviation] age = 51.64 [11.24] years; 33% female) taken from the Midlife in the United States study. Perceived control and daily discrimination were assessed via self-report, and inflammation was measured via circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, and tumor necrosis factor α. Cardiovascular health was measured by morbidity of cardiovascular conditions: heart disease, hypertension, and/or stroke. ResultsCRP (indirect effect:b =0.004, 95% confidence interval [CI] = 0.001–0.007) and fibrinogen (indirect effect:b =0.002, 95% CI = 0.0003–0.005) mediated the link between discrimination and cardiovascular conditions. Perceived control moderated the relationship between discrimination and CRP (F(1, 293) = 4.58, ΔR²= 0.013,b= −0.02, SE = 0.01,p= .033). CRP mediated the link between discrimination and cardiovascular conditions only for those who reported low levels of perceived control (Index = −0.003, 95% CI = −0.007 to −0.0001). ConclusionFindings provide empirical evidence of inflammation as a mechanism linking discrimination to cardiovascular conditions among Black Americans. Additionally, perceived control may be protective. Findings could suggest beliefs about control as a potential intervention target to help reduce the negative effects of discrimination on cardiovascular health among Black Americans. 

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5. Ethnic–Racial Discrimination Exposure and Anxiety in Latina Girls: Amygdala Volume as an Indirect Neurobiological Pathway

   https://doi.org/10.1007/s11577-024-00946-2  

   Mullins, Jordan_L; Díaz, Dana_E; Firat, Rengin_B; Michalska, Kalina_J (April 2024, KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie)

   Abstract Ethnic–racial discrimination, the differential treatment of individuals based on ethnic or racial group membership, predicts poor mental health outcomes such as anxiety. This is supported by long-standing theories on the social determinants of health and minority stress. However, these theories are rarely expanded to neurobiological sciences, limiting our understanding of mechanisms underlying observed associations. One potential neurobiological pathway between ethnic–racial discrimination exposure and anxiety is that ongoing exposure to racially charged encounters presents imminent threats that may modify stress-sensitive neurocircuitry, like the amygdala. The current study evaluated whether amygdala volume mediated associations between ethnic–racial discrimination exposure and anxiety symptoms in Latina girls, a group exhibiting heightened levels of untreated anxiety and disproportionately subjected to ethnic–racial discrimination. Thirty predominantly Mexican-identifying Latina girls residing in Southern California (M_Age = 9.76,SD = 1.11 years) completed a T1-weighted structural MRI scan. Using thePerceptions of Racism in Children and Youth, participants self-reported the prevalence and severity of various discriminatory experiences. Participants also self-reported their anxiety symptoms via theScreen for Child Anxiety and Related Emotional Disorders.Controlling for total intracranial volume and annual household income, an indirect effect of ethnic–racial discrimination on anxiety symptoms via left amygdala volume was observed,β = −0.28,SE = 0.17, BC 95% CI [−0.690, −0.017]. The current findings suggest that the left amygdala is sensitive to racialized threats in childhood and that stress-related alterations may, in part, contribute to elevated anxiety in Latina girls. Our data elucidate a potential mechanism by which this form of sociocultural stress can adversely impact mental health, particularly in the transition from middle childhood to early adolescence, a period marked by a host of interlinked neurophysiological and social changes. 

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