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Abstract Indole is one of the most important heterocycles in organic synthesis, natural products, and drug discovery. Recently, tremendous advances in the selective functionalization of indoles have been reported. Although the most important advances have been powered by transition metal catalysis, exceedingly useful methods in the absence of transition metals have also been reported. In this review, we provide an overview of functionalization reactions of indoles that have been published in the last years with a focus on the most recent advances, aims, and future trends. The review is organized by the positional selectivity and type of methods used for functionalization. In particular, we discuss major advances in transition‐metal‐catalyzed C−H functionalization at the classical C2/C3 positions, transition‐metal‐catalyzed C−H functionalization at the remote C4/C7 positions, transition‐metal‐catalyzed cross‐coupling, and transition‐metal‐free functionalization. magnified image
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Phosphorus‐Directed C−H Borylation
Abstract Phosphorus‐containing compounds have a long history of utility in a broad range of fields, including agricultural, pharmaceutical, and metal‐mediated reactions. In recent decades, numerous methods have been developed to streamline the synthesis of organophosphorus reagents based on these numerous applications. This review focuses upon the recent development of phosphorus(III)‐ and phosphorus(V)‐directed C−H borylation reactions. This transformation has evolved significantly in the past two years, resulting in several new methods that provide access to organic substrates containing both phosphorus and boron. Further functionalization of the carbon−boron bond to provide functionalized organophosphorus products is discussed. magnified image
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- Award ID(s):
- 1764307
- PAR ID:
- 10452189
- Publisher / Repository:
- Wiley Blackwell (John Wiley & Sons)
- Date Published:
- Journal Name:
- Advanced Synthesis & Catalysis
- Volume:
- 363
- Issue:
- 9
- ISSN:
- 1615-4150
- Page Range / eLocation ID:
- p. 2354-2365
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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