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Title: Biomaterial Drug Delivery Systems for Prominent Ocular Diseases
Ocular diseases, such as age-related macular degeneration (AMD) and glaucoma, have had a profound impact on millions of patients. In the past couple of decades, these diseases have been treated using conventional techniques but have also presented certain challenges and limitations that affect patient experience and outcomes. To address this, biomaterials have been used for ocular drug delivery, and a wide range of systems have been developed. This review will discuss some of the major classes and examples of biomaterials used for the treatment of prominent ocular diseases, including ocular implants (biodegradable and non-biodegradable), nanocarriers (hydrogels, liposomes, nanomicelles, DNA-inspired nanoparticles, and dendrimers), microneedles, and drug-loaded contact lenses. We will also discuss the advantages of these biomaterials over conventional approaches with support from the results of clinical trials that demonstrate their efficacy.  more » « less
Award ID(s):
2025362 2234570 1905785
NSF-PAR ID:
10456089
Author(s) / Creator(s):
; ; ; ; ; ;
Publisher / Repository:
MDPI
Date Published:
Journal Name:
Pharmaceutics
Volume:
15
Issue:
7
ISSN:
1999-4923
Page Range / eLocation ID:
1959
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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