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Title: Lipoic acid-based poly(disulfide)s: Synthesis and biomedical applications
Biodegradable and adaptable polymeric materials are currently being studied due to their wide scope of potential applications, from nanomedicine to novel multifunctional materials. One such class of polymers are poly(disulfide)s, which contain repeating disulfide bonds in their main chain. Lipoic acid, or thioctic acid, is a biologically derived small molecule containing a 1,2-dithiolane ring capable of undergoing ring opening polymerization to yield poly(disulfide)s. In this review, we highlight the synthesis of lipoic acid-based poly(disulfide)s through thermal and thiolate-initiated ring opening polymerizations, and the development of methodology pertaining to the synthetic methods. We further discuss the biomedical applications of poly(disulfide)s, which have been widely used to construct various responsive biomaterials, including polymer-drug conjugates, nanoparticles, hydrogels, and adhesives.  more » « less
Award ID(s):
2238812
PAR ID:
10481929
Author(s) / Creator(s):
; ; ; ;
Editor(s):
Ye, Qingsong
Publisher / Repository:
KeAi publishing
Date Published:
Journal Name:
Nano TransMed
Volume:
2
Issue:
2-3
ISSN:
2790-6760
Page Range / eLocation ID:
100006
Subject(s) / Keyword(s):
Poly(disulfide)s Lipoic acid Ring-opening polymerization Nanomedicine Drug delivery
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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