Early diagnosis of Alzheimer’s Disease (AD) is challenging due to its progressive nature. This study proposes a comprehensive comparison of four classifiers combined with different dimensionality reduction methods to discriminate normal controls (CN) from pre-mild cognitive impairment (pMCI) and early MCI (EMCI) using multimodal datasets including MRIs, PETs, SUVr, clinician amyloid visual reads, and subjects demographics. The most robust classifier for CN vs. MCI is the Mutual Information Best Percentile - Bagging Classifier
combination, with 73.91% accuracy and a 4.82% standard deviation (SD). The best performance of 65.23% (11.84% SD) accuracy for CN vs. EMCI was DTC with ANOVA. In comparing CN with pMCI the best classification accuracy was ANOVA-DTC 51.06% (14.19% SD). An accuracy of 56.34% (10.67% SD) was achieved by bagging with ANOVA for multiclass classification ofCN vs. pMCI vs. EMCI.
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A transfer learning approach based on gradient boosting machine for diagnosis of Alzheimer’s disease
Early detection of Alzheimer’s disease (AD) during the Mild Cognitive Impairment (MCI) stage could enable effective intervention to slow down disease progression. Computer-aided diagnosis of AD relies on a sufficient amount of biomarker data. When this requirement is not fulfilled, transfer learning can be used to transfer knowledge from a source domain with more amount of labeled data than available in the desired target domain. In this study, an instance-based transfer learning framework is presented based on the gradient boosting machine (GBM). In GBM, a sequence of base learners is built, and each learner focuses on the errors (residuals) of the previous learner. In our transfer learning version of GBM (TrGB), a weighting mechanism based on the residuals of the base learners is defined for the source instances. Consequently, instances with different distribution than the target data will have a lower impact on the target learner. The proposed weighting scheme aims to transfer as much information as possible from the source domain while avoiding negative transfer. The target data in this study was obtained from the Mount Sinai dataset which is collected and processed in a collaborative 5-year project at the Mount Sinai Medical Center. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset was used as the source domain. The experimental results showed that the proposed TrGB algorithm could improve the classification accuracy by 1.5 and 4.5% for CN vs. MCI and multiclass classification, respectively, as compared to the conventional methods. Also, using the TrGB model and transferred knowledge from the CN vs. AD classification of the source domain, the average score of early MCI vs. late MCI classification improved by 5%.
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- NSF-PAR ID:
- 10458501
- Date Published:
- Journal Name:
- Frontiers in Aging Neuroscience
- Volume:
- 14
- ISSN:
- 1663-4365
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.3389/fnagi.2022.966883
