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Title: Mrs4 loss of function in fungi during adaptation to the cystic fibrosis lung
The identification of MRS4 mutations in Clavispora ( Candida ) lusitaniae and Exophiala dermatitidis in individuals with cystic fibrosis (CF) highlights a possible adaptive mechanism for fungi during chronic CF lung infections. The findings of this study suggest that loss of function of the mitochondrial iron transporter Mrs4 can lead to increased activity of iron acquisition mechanisms, which may be advantageous for fungi in iron-restricted environments during chronic infections. This study provides valuable information for researchers working toward a better understanding of the pathogenesis of chronic lung infections and more effective therapies to treat them.  more » « less
Award ID(s):
2215705
PAR ID:
10464599
Author(s) / Creator(s):
; ; ; ; ; ;
Editor(s):
Alspaugh, J. Andrew
Date Published:
Journal Name:
Mycology
ISSN:
2452-0780
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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