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1. Reduced Order Models for the Quasi-Geostrophic Equations: A Brief Survey

   https://doi.org/10.3390/fluids6010016  

   Mou, Changhong ; Wang, Zhu ; Wells, David R. ; Xie, Xuping ; Iliescu, Traian ( January 2021 , Fluids)

   null (Ed.)

   Reduced order models (ROMs) are computational models whose dimension is significantly lower than those obtained through classical numerical discretizations (e.g., finite element, finite difference, finite volume, or spectral methods). Thus, ROMs have been used to accelerate numerical simulations of many query problems, e.g., uncertainty quantification, control, and shape optimization. Projection-based ROMs have been particularly successful in the numerical simulation of fluid flows. In this brief survey, we summarize some recent ROM developments for the quasi-geostrophic equations (QGE) (also known as the barotropic vorticity equations), which are a simplified model for geophysical flows in which rotation plays a central role, such as wind-driven ocean circulation in mid-latitude ocean basins. Since the QGE represent a practical compromise between efficient numerical simulations of ocean flows and accurate representations of large scale ocean dynamics, these equations have often been used in the testing of new numerical methods for ocean flows. ROMs have also been tested on the QGE for various settings in order to understand their potential in efficient numerical simulations of ocean flows. In this paper, we survey the ROMs developed for the QGE in order to understand their potential in efficient numerical simulations of more complex ocean flows: We explain how classical numerical methods for the QGE are used to generate the ROM basis functions, we outline the main steps in the construction of projection-based ROMs (with a particular focus on the under-resolved regime, when the closure problem needs to be addressed), we illustrate the ROMs in the numerical simulation of the QGE for various settings, and we present several potential future research avenues in the ROM exploration of the QGE and more complex models of geophysical flows. 

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2. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

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3. Deep Learning Methods for Sign Language Translation

   https://doi.org/10.1145/3477498  

   Ananthanarayana, Tejaswini ; Srivastava, Priyanshu ; Chintha, Akash ; Santha, Akhil ; Landy, Brian ; Panaro, Joseph ; Webster, Andre ; Kotecha, Nikunj ; Sah, Shagan ; Sarchet, Thomastine ; et al ( December 2021 , ACM Transactions on Accessible Computing)

   Many sign languages are bona fide natural languages with grammatical rules and lexicons hence can benefit from machine translation methods. Similarly, since sign language is a visual-spatial language, it can also benefit from computer vision methods for encoding it. With the advent of deep learning methods in recent years, significant advances have been made in natural language processing (specifically neural machine translation) and in computer vision methods (specifically image and video captioning). Researchers have therefore begun expanding these learning methods to sign language understanding. Sign language interpretation is especially challenging, because it involves a continuous visual-spatial modality where meaning is often derived based on context. The focus of this article, therefore, is to examine various deep learning–based methods for encoding sign language as inputs, and to analyze the efficacy of several machine translation methods, over three different sign language datasets. The goal is to determine which combinations are sufficiently robust for sign language translation without any gloss-based information. To understand the role of the different input features, we perform ablation studies over the model architectures (input features + neural translation models) for improved continuous sign language translation. These input features include body and finger joints, facial points, as well as vector representations/embeddings from convolutional neural networks. The machine translation models explored include several baseline sequence-to-sequence approaches, more complex and challenging networks using attention, reinforcement learning, and the transformer model. We implement the translation methods over multiple sign languages—German (GSL), American (ASL), and Chinese sign languages (CSL). From our analysis, the transformer model combined with input embeddings from ResNet50 or pose-based landmark features outperformed all the other sequence-to-sequence models by achieving higher BLEU2-BLEU4 scores when applied to the controlled and constrained GSL benchmark dataset. These combinations also showed significant promise on the other less controlled ASL and CSL datasets. 

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4. Work in Progress: Using Machine Learning to Map Student Narratives of Understanding and Promoting Linguistic Justice

   Auby, H. ; Koretsky, M. ( June 2023 , 2023 ASEE Annual Conference & Exposition)

   his work-in-progress paper expands on a collaboration between engineering education researchers and machine learning researchers to automate the analysis of written responses to conceptually challenging questions in statics and dynamics courses (Authors, 2022). Using the Concept Warehouse (Koretsky et al., 2014), written justifications of ConcepTests (CTs) were gathered from statics and dynamics courses in a diverse set of two- and four-year institutions. Written justifications for CTs have been used to support active learning pedagogies which makes them important to investigate how students put together their problem-solving narratives of understanding. However, despite the large benefit that analysis of student written responses may provide to instructors and researchers, manual review of responses is cumbersome, limits analysis, and can be prone to human bias. In efforts to improve the analysis of student written responses, machine learning has been used in various educational contexts to analyze short and long texts (Burstein et al., 2020; Burstein et al., 2021). Natural Language Processing (NLP) uses transformer-based machine learning models (Brown et al., 2020; Raffel et al., 2019) which can be used through fine-tuning or in-context learning methods. NLP can be used to train algorithms that can automate the coding of written responses. Only a few studies for educational applications have leveraged transformer-based machine learning models further prompting an investigation into its use in STEM education. However, work in NLP has been criticized for heightening the possibility to perpetuate and even amplify harmful stereotypes and implicit biases (Chang et al., 2019; Mayfield et al., 2019). In this study, we detail the aim to use NLP for linguistic justice. Using methods like text summary, topic modeling, and text classification, we identify key aspects of student narratives of understanding in written responses to mechanics and statics CTs. Through this process, we seek to use machine learning to identify different ways students talk about a problem and their understanding at any point in their narrative formation process. Thus, we hope to help reduce human bias in the classroom and through technology by giving instructors and researchers a diverse set of narratives that include insight into their students’ histories, identities, and understanding. These can then be used towards connecting technological knowledge to students’ everyday lives. 

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5. Using transformers to provide teachers with personalized feedback on their classroom discourse: The TalkMoves application

   Suresh, A. ; Jacobs, J. ; Lai, V. ; Tan, C. ; Ward, W. ; Martin, J.H. ; Sumner, T. ( January 2021 , Association for the Advancement of Artificial Intelligence)

   null (Ed.)

   TalkMoves is an innovative application designed to support K-12 mathematics teachers to reflect on, and continuously improve their instructional practices. This application combines state-of-the-art natural language processing capabilities with automated speech recognition to automatically analyze classroom recordings and provide teachers with personalized feedback on their use of specific types of discourse aimed at broadening and deepening classroom conversations about mathematics. These specific discourse strategies are referred to as “talk moves” within the mathematics education community and prior research has documented the ways in which systematic use of these discourse strategies can positively impact student engagement and learning. In this article, we describe the TalkMoves application’s cloud-based infrastructure for managing and processing classroom recordings, and its interface for providing teachers with feedback on their use of talk moves during individual teaching episodes. We present the series of model architectures we developed, and the studies we conducted, to develop our best-performing, transformer-based model (F1 = 79.3%). We also discuss several technical challenges that need to be addressed when working with real-world speech and language data from noisy K-12 classrooms. 

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