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1. ADAPT: An Event-Based Adaptive Collective Communication Framework

   https://doi.org/10.1145/3208040.3208054  

   Luo, Xi ; Wu, Wei ; Bosilca, George ; Patinyasakdikul, Thananon ; Wang, Linnan ; Dongarra, Jack ( June 2018 , The 27th International Symposium on High-Performance Parallel and Distributed Computing)

   The increase in scale and heterogeneity of high-performance computing (HPC) systems predispose the performance of Message Passing Interface (MPI) collective communications to be susceptible to noise, and to adapt to a complex mix of hardware capabilities. The designs of state of the art MPI collectives heavily rely on synchronizations; these designs magnify noise across the participating processes, resulting in significant performance slowdown. Therefore, such design philosophy must be reconsidered to efficiently and robustly run on the large-scale heterogeneous platforms. In this paper, we present ADAPT, a new collective communication framework in Open MPI, using event-driven techniques to morph collective algorithms to heterogeneous environments. The core concept of ADAPT is to relax synchronizations, while mamtaining the minimal data dependencies of MPI collectives. To fully exploit the different bandwidths of data movement lanes in heterogeneous systems, we extend the ADAPT collective framework with a topology-aware communication tree. This removes the boundaries of different hardware topologies while maximizing the speed of data movements. We evaluate our framework with two popular collective operations: broadcast and reduce on both CPU and GPU clusters. Our results demonstrate drastic performance improvements and a strong resistance against noise compared to other state of the art MPI libraries. In particular, we demonstrate at least 1.3X and 1.5X speedup for CPU data and 2X and 10X speedup for GPU data using ADAPT event-based broadcast and reduce operations. 

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2. Learning and Communications Co-Design for Remote Inference Systems: Feature Length Selection and Transmission Scheduling

   https://doi.org/10.1109/JSAIT.2023.3322620  

   Shisher, Md Kamran ; Ji, Bo ; Hou, I-Hong ; Sun, Yin ( January 2023 , IEEE Journal on Selected Areas in Information Theory)

   In this paper, we consider a remote inference system, where a neural network is used to infer a time-varying target (e.g., robot movement), based on features (e.g., video clips) that are progressively received from a sensing node (e.g., a camera). Each feature is a temporal sequence of sensory data. The inference error is determined by (i) the timeliness and (ii) the sequence length of the feature, where we use Age of Information (AoI) as a metric for timeliness. While a longer feature can typically provide better inference performance, it often requires more channel resources for sending the feature. To minimize the time-averaged inference error, we study a learning and communication co-design problem that jointly optimizes feature length selection and transmission scheduling. When there is a single sensor-predictor pair and a single channel, we develop low-complexity optimal co-designs for both the cases of time-invariant and time-variant feature length. When there are multiple sensor-predictor pairs and multiple channels, the co-design problem becomes a restless multi-arm multi-action bandit problem that is PSPACE-hard. For this setting, we design a low-complexity algorithm to solve the problem. Trace-driven evaluations demonstrate the potential of these co-designs to reduce inference error by up to 10000 times. 

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3. Evaluation of Docker Containers for Scientific Workloads in theCloud

   Saha, Pankaj ; Beltre, Angel ; Uminski, Piotr ; Govindaraju, Madhusudhan ( July 2018 , Practice and Experience in Advanced Research Computing (PEARC), 2018.)

   The HPC community is actively researching and evaluating tools to support execution of scientific applications in cloud-based environ- ments. Among the various technologies, containers have recently gained importance as they have significantly better performance compared to full-scale virtualization, support for microservices and DevOps, and work seamlessly with workflow and orchestration tools. Docker is currently the leader in containerization technology because it offers low overhead, flexibility, portability of applications, and reproducibility. Singularity is another container solution that is of interest as it is designed specifically for scientific applications. It is important to conduct performance and feature analysis of the container technologies to understand their applicability for each application and target execution environment. This paper presents a (1) performance evaluation of Docker and Singularity on bare metal nodes in the Chameleon cloud (2) mecha- nism by which Docker containers can be mapped with InfiniBand hardware with RDMA communication and (3) analysis of mapping elements of parallel workloads to the containers for optimal re- source management with container-ready orchestration tools. Our experiments are targeted toward application developers so that they can make informed decisions on choosing the container tech- nologies and approaches that are suitable for their HPC workloads on cloud infrastructure. Our performance analysis shows that sci- entific workloads for both Docker and Singularity based containers can achieve near-native performance. Singularity is designed specifically for HPC workloads. However, Docker still has advantages over Singularity for use in clouds as it provides overlay networking and an intuitive way to run MPI applications with one container per rank for fine-grained resources allocation. Both Docker and Singularity make it possible to directly use the underlying network fabric from the containers for coarse- grained resource allocation. 

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4. Design of a Portable Implementation of Partitioned Point-to-Point Communication Primitives

   https://doi.org/10.1145/3458744.3474046  

   Worley, Andrew ; Prema Soundararajan, Prema ; Schafer, Derek ; Bangalore, Purushotham ; Grant, Ryan ; Dosanjh, Matthew ; Skjellum, Anthony ; Ghafoor, Sheikh ( July 2021 , ICPP Workshops '21: 50th International Conference on Parallel Processing Workshop)

   null (Ed.)

   The Message Passing Interface (MPI) has been the dominant message passing solution for scientific computing for decades. MPI point-to-point communications are highly efficient mechanisms for process-to- process communication. However, MPI performance is slowed by concurrency protections in the MPI library when processes utilize multiple threads. MPI’s current thread-level interface imposes these overheads throughout the library when thread safety is needed. While much work has been done to reduce multithreading overheads in MPI, a solution is needed that reduces the number of messages exchanged in a threaded environment. Partitioned communication is included in the MPI 4.0 standard as an alternative that addresses the challenges of multithreaded communication in MPI today. Partitioned communication reduces overall message volume by creating a buffer-sharing mechanism between threads such that they can indicate when portions of a communication buffer are available to be sent. Separation of the control and data planes in MPI is enabled by allowing persistent initialization and single occurrence message buffer matching from the indication that the data is ready to be sent. This enables the usage commands (destination, size, etc.) can be set up prior to data buffer readiness with readiness triggered by a simple doorbell/counter later. This approach is useful for future development of MPI operations in environments where traditional networking commands can have performance challenges, like accelerators (GPUs, FPGAs). In this paper,we detail the design and implementation of a layered library (built on top of MPI-3.1) and an integrated Open MPI solution that supports the new, MPI-4.0 partitioned communication feature set. The library will enable applications to use currently released MPI implementations and older legacy libraries to provide partitioned communication support while also enabling further exploration of this new communication model in new applications and use cases. We will compare the designs of the library and native Open MPI support, provide performance results and comparisons between the two approaches, and lessons learned from the implementation of partitioned communication in both library and native forms. We find that the native implementation and library have similar performance with a percentage difference under 0.94% in microbenchmarks and performance within 5% for a partitioned communication enabled proxy application. 

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5. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do not have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA. 

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