Abstract A search for resonances in top quark pair ( ) production in final states with two charged leptons and multiple jets is presented, based on proton–proton collision data collected by the CMS experiment at the CERN LHC at , corresponding to 138 fb−1. The analysis explores the invariant mass of the system and two angular observables that provide direct access to the correlation of top quark and antiquark spins. A significant excess of events is observed near the kinematic threshold compared to the non-resonant production predicted by fixed-order perturbative quantum chromodynamics (pQCD). The observed enhancement is consistent with the production of a color-singlet pseudoscalar ( ) quasi-bound toponium state, as predicted by non-relativistic quantum chromodynamics. Using a simplified model for toponium, the cross section of the excess above the pQCD prediction is measured to be .
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Cardiac phase-resolved late gadolinium enhancement imaging
Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is the clinical reference for assessment of myocardial scar and focal fibrosis. However, current LGE techniques are confined to imaging of a single cardiac phase, which hampers assessment of scar motility and does not allow cross-comparison between multiple phases. In this work, we investigate a three step approach to obtain cardiac phase-resolved LGE images: (1) Acquisition of cardiac phase-resolved imaging data with varyingT1weighting. (2) Generation of semi-quantitative maps for each cardiac phase. (3) Synthetization of LGE contrast to obtain functional LGE images. The proposed method is evaluated in phantom imaging, six healthy subjects at 3T and 20 patients at 1.5T. Phantom imaging at 3T demonstrates consistent contrast throughout the cardiac cycle with a coefficient of variation of 2.55 ± 0.42%.In-vivoresults show reliable LGE contrast with thorough suppression of the myocardial tissue is healthy subjects. The contrast between blood and myocardium showed moderate variation throughout the cardiac cycle in healthy subjects (coefficient of variation 18.2 ± 3.51%). Images were acquired at 40–60 ms and 80 ms temporal resolution, at 3T and 1.5, respectively. Functional LGE images acquired in patients with myocardial scar visualized scar tissue throughout the cardiac cycle, albeit at noticeably lower imaging resolution and noise resilience than the reference technique. The proposed technique bears the promise of integrating the advantages of phase-resolved CMR with LGE imaging, but further improvements in the acquisition quality are warranted for clinical use.
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- Award ID(s):
- 1651825
- PAR ID:
- 10469960
- Publisher / Repository:
- Front Cardiovasc Med
- Date Published:
- Journal Name:
- Frontiers in Cardiovascular Medicine
- Volume:
- 9
- ISSN:
- 2297-055X
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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