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1. Comparison of thermo-poroelastic and thermo-poroelastoplastic constitutive models to analyze THM process in clays

   https://doi.org/10.1051/e3sconf/202020504008  

   Mir Tamizdoust, Mohammadreza; Ghasemi-Fare, Omid (January 2020, E3S Web of Conferences)

   McCartney, J.S.; Tomac, I. (Ed.)

   Thermal pore pressurization in soil media has been investigated for the past few decades. It has been shown that temperature variations may significantly affect thermal pore pressure in clay soils confined deep into the ground. Moreover, thermal loading may lead to stress change and thermal deformation. Thermo-poroelastic and advance thermo-poroelastoplastic constitutive models have been formulated and incorporated numerically to simulate the thermo-hydro-mechanical process. However, the accurate response of soil media during THM process has not been completely understood. Although numerical modelling reasonably predicts the experimental observations, they still could not be used to completely justify the field observations. In this study, the main features of the thermo-poroelastic model are incorporated in a thermo-poroelastoplastic constitutive model (ACMEG-T) to further investigate the effect of different thermal and hydraulic properties on thermo-hydro-mechanical (THM) response of the soil media. 

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2. Vitrification and Rewarming of Magnetic Nanoparticle‐Loaded Rat Hearts

   https://doi.org/10.1002/admt.202100873  

   Gao, Zhe; Namsrai, Baterdene; Han, Zonghu; Joshi, Purva; Rao, Joseph_Sushil; Ravikumar, Vasanth; Sharma, Anirudh; Ring, Hattie_L; Idiyatullin, Djaudat; Magnuson, Elliott_C; et al (October 2021, Advanced Materials Technologies)

   Abstract To extend the preservation of donor hearts beyond the current 4–6 h, this paper explores heart cryopreservation by vitrification—cryogenic storage in a glass‐like state. While organ vitrification is made possible by using cryoprotective agents (CPA) that inhibit ice during cooling, failure occurs during convective rewarming due to slow and non‐uniform rewarming which causes ice crystallization and/or cracking. Here an alternative, “nanowarming”, which uses silica‐coated iron oxide nanoparticles (sIONPs) perfusion loaded through the vasculature is explored, that allows a radiofrequency coil to rewarm the organ quickly and uniformly to avoid convective failures. Nanowarming has been applied to cells and tissues, and a proof of principle study suggests it is possible in the heart, but proper physical and biological characterization especially in organs is still lacking. Here, using a rat heart model, controlled machine perfusion loading and unloading of CPA and sIONPs, cooling to a vitrified state, and fast and uniform nanowarming without crystallization or cracking is demonstrated. Further, nanowarmed hearts maintain histologic appearance and endothelial integrity superior to convective rewarming and indistinguishable from CPA load/unload control hearts while showing some promising organ‐level (electrical) functional activity. This work demonstrates physically successful heart vitrification and nanowarming and that biological outcomes can be expected to improve by reducing or eliminating CPA toxicity during loading and unloading. 

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3. Thermomechanical stress analyses of nanowarming-assisted recovery from cryopreservation by vitrification in human heart and rat heart models

   https://doi.org/10.1371/journal.pone.0290063  

   Joshi, Purva; Rabin, Yoed (August 2023, PLOS ONE)

   Bentley, Barry L. (Ed.)

   This study investigates thermomechanical stress in cryopreservation by vitrification of the heart, while exploring the effects of nanowarming-assisted recovery from cryogenic storage. This study expands upon a recently published study, combining experimental investigation and thermal analysis of cryopreservation on a rat heart model. Specifically, this study focuses on scenarios with variable concentrations of silica-coated iron-oxide nanoparticles (sIONPs), while accounting for loading limitations associated with the heart physiology, as well as the properties of cryoprotective agent (CPA) solution and the geometry of the container. Results of this study suggest that variable sIONP concentration based on the heart physiology will elevate mechanical stresses when compared with the mathematically simplified, uniform distribution case. The most dangerous part of rewarming is below glass transition and at the onset of nanowarming past the glass transition temperature on the way for organ recovery from cryogenic storage. Throughout rewarming, regions that rewarm faster, such as the chambers of the heart (higher sIONP concentration), undergo compressive stresses, while the slower rewarming regions, such as the heart myocardium (low sIONP concentration), undergo tension. Being a brittle material, the vitrified organ is expected to fail under tension in lower stresses than in compression. Unfortunately, the location and magnitude of the maximum stress in the investigated cases varied, while general rules were not identified. This investigation demonstrates the need to tailor the thermal protocol of heart cryopreservation on a case-by-case basis, since the location, orientation, magnitude, and instant at which the maximum mechanical stress is found cannot be predicteda priori. While thermomechanical stress poses a significant risk to organ integrity, careful design of the thermal protocol can be instrumental in reducing the likelihood of structural damage, while taking full advantage of the benefits of nanowarming. 

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4. Pulsatile flow in a thin-walled viscoelastic tube

   https://doi.org/10.1017/jfm.2025.150  

   Krul, Oleksander; Bagchi, Prosenjit (March 2025, Journal of Fluid Mechanics)

   Low-inertia pulsatile flows in highly distensible viscoelastic vessels exist in many biological and engineering systems. However, many existing works focus on inertial pulsatile flows in vessels with small deformations. As such, here we study the dynamics of a viscoelastic tube at large deformation conveying low-Reynolds-number oscillatory flow using a fully coupled fluid–structure interaction computational model. We focus on a detailed study of the effect of wall (solid) viscosity and oscillation frequency on tube deformation, flow rate, phase shift and hysteresis, as well as the underlying flow physics. We find that the general behaviour is dominated by an elastic flow surge during inflation and a squeezing effect during deflation. When increasing the oscillation frequency, the maximum inlet flow rate increases and tube distention decreases, whereas increasing solid viscosity causes both to decrease. As the oscillation frequency approaches either$$0$$(quasi-steady inflation cycle) or$$\infty$$(steady flow), the behaviours of tubes with different solid viscosities converge. Our results suggest that deformation and flow rate are most affected in the intermediate range of solid viscosity and oscillation frequency. Phase shifts of deformation and flow rate with respect to the imposed pressure are analysed. We predict that the phase shifts vary throughout the oscillation; while the deformation always lags the imposed pressure, the flow rate may either lead or lag depending on the parameter values. As such, the flow rate shows hysteresis behaviour that traces either a clockwise or counterclockwise curve, or a mix of both, in the pressure–flow rate space. This directional change in hysteresis is fully characterised here in the appropriate parameter space. Furthermore, the hysteresis direction is shown to be predicted by the signs of the flow rate phase shifts at the crest and trough of the oscillation. A distinct change in the tube dynamics is also observed at high solid viscosity which leads to global or ‘whole-tube’ motion that is absent in purely elastic tubes. 

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5. Thermal shakedown in granular materials with irregular particle shapes

   https://doi.org/10.1038/s41598-024-57503-2  

   Pan, Yize; Gong, Xiaohui; Rotta Loria, Alessandro F. (March 2024, Scientific Reports)

   Abstract Granular materials with irregular particle shapes undergo a myriad of temperature variations in natural and engineered systems. However, the impacts of cyclic temperature variations on the mechanics of granular materials remain poorly understood. Specifically, little is known about the response of granular materials to cyclic temperature variations as a function of the following central variables: particle shape, applied stress level, relative density, and temperature amplitude. This paper presents advanced laboratory experiments to explore the impacts of cyclic temperature variations on the mechanics of granular materials, with a focus on sands. The results show that cyclic temperature variations applied to sands induce thermal shakedown: the accumulation of irreversible bulk deformations due to microstructural rearrangements caused by thermal expansions and contractions of the constituting particles. The deformation of sands caused by thermal shakedown strongly depends on particle shape, stress level, relative density, and temperature amplitude. This deformation is limited for individual thermal cycles but accumulates and becomes significant for multiple thermal cycles, leading to substantial compaction in sands and other granular materials, which can affect various natural and engineered systems. 

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