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Artificial Intelligence (AI) systems for mental healthcare (MHCare) have been ever-growing after realizing the importance of early interventions for patients with chronic mental health (MH) conditions. Social media (SocMedia) emerged as the go-to platform for supporting patients seeking MHCare. The creation of peer-support groups without social stigma has resulted in patients transitioning from clinical settings to SocMedia supported interactions for quick help. Researchers started exploring SocMedia content in search of cues that showcase correlation or causation between different MH conditions to design better interventional strategies. User-level Classification-based AI systems were designed to leverage diverse SocMedia data from various MH conditions, to predict MH conditions. Subsequently, researchers created classification schemes to measure the severity of each MH condition. Such ad-hoc schemes, engineered features, and models not only require a large amount of data but fail to allow clinically acceptable and explainable reasoning over the outcomes. To improve Neural-AI for MHCare, infusion of clinical symbolic knowledge that clinicans use in decision making is required. An impactful use case of Neural-AI systems in MH is conversational systems. These systems require coordination between classification and generation to facilitate humanistic conversation in conversational agents (CA). Current CAs with deep language models lack factual correctness, medical relevance, and safety in their generations, which intertwine with unexplainable statistical classification techniques. This lecture-style tutorial will demonstrate our investigations into Neuro-symbolic methods of infusing clinical knowledge to improve the outcomes of Neural-AI systems to improve interventions for MHCare:(a) We will discuss the use of diverse clinical knowledge in creating specialized datasets to train Neural-AI systems effectively. (b) Patients with cardiovascular disease express MH symptoms differently based on gender differences. We will show that knowledge-infused Neural-AI systems can identify gender-specific MH symptoms in such patients. (c) We will describe strategies for infusing clinical process knowledge as heuristics and constraints to improve language models in generating relevant questions and responses.
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Foundation models for generalist medical artificial intelligence
The exceptionally rapid development of highly flexible, reusable artificial intelligence (AI) models is likely to usher in newfound capabilities in medicine. We proposed a new paradigm for medical AI, which we refer to as generalist medical AI (GMAI). GMAI models will be capable of carrying out a diverse set of tasks using very little or no task-specific labelled data. Built through self-supervision on large, diverse datasets, GMAI will flexibly interpret different combinations of medical modalities, including data from imaging, electronic health records, laboratory results, genomics, graphs or medical text. Models will in turn produce expressive outputs such as free-text explanations, spoken recommendations or image annotations that demonstrate advanced medical reasoning abilities. We identified a set of high-impact potential applications for GMAI and laid out specific technical capabilities and training datasets necessary to enable them. We expect that GMAI-enabled applications will challenge current strategies for regulating and validating AI devices for medicine and will shift practices associated with the collection of large medical datasets.
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- PAR ID:
- 10471867
- Publisher / Repository:
- Nature
- Date Published:
- Journal Name:
- Nature
- Volume:
- 616
- Issue:
- 7956
- ISSN:
- 0028-0836
- Page Range / eLocation ID:
- 259 to 265
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1038/s41586-023-05881-4
