Zika virus (ZIKV) is an increasing global health challenge. There is an urgent need for rapid, low‐cost, and accurate diagnostic tests that can be broadly distributed and applied in pandemic regions. Here, an innovative, adaptable, and rapidly deployable bioplasmonic paper‐based device (BPD) is demonstrated for the detection of ZIKV infection, via quantification of serum anti‐ZIKV‐nonstructural protein 1 (NS1) IgG and IgM. BPD is based on ZIKV‐NS1 protein as a capture element and gold nanorods as plasmonic nanotransducers. The BPD displays excellent sensitivity and selectivity to both anti‐ZIKV‐NS1 IgG and IgM in human serum. In addition, excellent stability of BPDs at room and even elevated temperature for one month is achieved by metal–organic framework (MOF)‐based biopreservation. MOF‐based preservation obviates the need for device refrigeration during transport and storage, thus enabling their use in point‐of‐care and resource‐limited settings for ZIKV surveillance. Furthermore, the versatile design (interchangeable recognition element) of BPDs more generally enables their ready adaptation to diagnose other emerging infectious diseases.
This content will become publicly available on October 24, 2024
- Award ID(s):
- 2239441
- NSF-PAR ID:
- 10473159
- Publisher / Repository:
- Royal Society of Chemistry
- Date Published:
- Journal Name:
- Nanoscale Advances
- ISSN:
- 2516-0230
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Obama, B., The irreversible momentum of clean energy.
Science 2017, 355 (6321), 126-129.Goodenough, J. B.; Park, K. S., The Li-ion rechargeable battery: a perspective.
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Nanomicro Lett 2022, 14 (1), 42.Yang, Q.; Li, Q.; Liu, Z.; Wang, D.; Guo, Y.; Li, X.; Tang, Y.; Li, H.; Dong, B.; Zhi, C., Dendrites in Zn-Based Batteries.
Adv Mater 2020, 32 (48), e2001854.Acknowledgment
This work was partially supported by the U.S. National Science Foundation (NSF) Award No. ECCS-1931088. S.L. and H.W.S. acknowledge the support from the Improvement of Measurement Standards and Technology for Mechanical Metrology (Grant No. 22011044) by KRISS.
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