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Title: Progress in 7SK ribonucleoprotein structural biology
The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa. Comprised of the non-coding 7SK RNA, core proteins, and numerous accessory proteins, the most well-known 7SK RNP function is the sequestration and inactivation of the positive transcription elongation factor b (P-TEFb). More recently, 7SK RNP has been shown to regulate RNAPII transcription through P-TEFb-independent pathways. Due to its fundamental role in cellular function, dysregulation has been linked with human diseases including cancers, heart disease, developmental disorders, and viral infection. Significant advances in 7SK RNP structural biology have improved our understanding of 7SK RNP assembly and function. Here, we review progress in understanding the structural basis of 7SK RNA folding, biogenesis, and RNP assembly.  more » « less
Award ID(s):
2047328
PAR ID:
10483204
Author(s) / Creator(s):
; ;
Publisher / Repository:
Frontiers
Date Published:
Journal Name:
Frontiers in Molecular Biosciences
Volume:
10
ISSN:
2296-889X
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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