Metformin is the first-line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally and entering wastewater. The drug’s direct mode of action is currently unknown but is linked to effects on gut microbiomes and may involve specific gut microbial reactions to the drug. In wastewater treatment plants, metformin is known to be transformed by microbes to guanylurea, although genes encoding this metabolism had not been elucidated. In the present study, we revealed the function of two genes responsible for metformin decomposition (
Recently, we reported the discovery of a novel endoglucanase of the glycoside hydrolase family 12 (GH12), designated IfCelS12A, from the haloalkaliphilic anaerobic bacterium
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- NSF-PAR ID:
- 10484906
- Publisher / Repository:
- Springer Science + Business Media
- Date Published:
- Journal Name:
- Applied Microbiology and Biotechnology
- Volume:
- 108
- Issue:
- 1
- ISSN:
- 0175-7598
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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