More Like this

1. Investigating partitioning of free versus macrocycle bound guest into a model POPC lipid bilayer

   https://doi.org/10.1039/d0ra02850a  

   Kumari, Harshita; Eisenhart, Andrew; Pajoubpong, Jinnipha; Heinrich, Frank; Beck, Thomas L. (April 2020, RSC Advances)

   null (Ed.)

   We report on the permeation of free and macrocycle-bound avobenzone across a POPC lipid bilayer through combined neutron reflectometry experiments and molecular dynamics simulations. Results indicate that the p -phosphonated calix[8]arene macrocycle limits the avobenzone penetration into the upper leaflet of the membrane. Hence, it could serve as a useful vehicle for safer formulations. 

   more » « less
2. Expanding the toolbox for supramolecular chemistry: probing host–guest interactions and binding with in situ FTIR spectroscopy

   https://doi.org/10.1039/D5SC01329A  

   Moaven, Shiva; Vander_Griend, Douglas A; Johnson, Darren W; Pluth, Michael D (May 2025, Chemical Science)

   In situFTIR spectroscopy can measureK_avalues across different classes of host–guest complexes involving hydrogen and halogen bonding. This approach requires minimal sample preparation and can track host or guest vibrational changes. 

   more » « less
3. Guest-Driven Control of Folding in a Crown-Ether-Functionalized ortho -Phenylene

   https://doi.org/10.1021/acs.joc.1c02605  

   Peddi, Sumalatha; Bookout, Molly C.; Vemuri, Gopi Nath; Hartley, C. Scott (March 2022, The Journal of Organic Chemistry)
4. Guest editorial

   https://doi.org/10.1108/ITP-10-2021-871  

   Dennehy, Denis; Pappas, Ilias O.; Wamba, Samuel Fosso; Michael, Katina (November 2021, Information Technology & People)
5. Impact of Guest Orientation in Host–Guest Supramolecular Hydrogels

   https://doi.org/10.1021/acsmacrolett.4c00531  

   Addonizio, Christopher J; Braegelman, Adam S; Schmidt, Connor R; Ollier, Rachel C; Antwi, Akwasi Ansah; Su, Bo; Farshad, Mohsen; Whitmer, Jonathan K; Webber, Matthew J (January 2025, ACS Macro Letters)

   Host–guest interactions have been increasingly explored for use in the dynamic physical crosslinking of polymeric precursors to form hydrogel networks. However, the orientation of guest motifs is restricted upon macromolecule conjugation. The implications of such restriction on both the kinetics and thermodynamics of the resulting host–guest supramolecular crosslinks are poorly understood. Herein, guest crosslinking motifs from controlled regioisomers are demonstrated to yield distinct material properties. Moreover, the underlying phenomena point to further unexpected impact of modular guest topology manifest on the molecular scale in both the affinity and dynamics of supramolecular complex formation. 

   more » « less