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   https://doi.org/10.1126/sciadv.abl8213  

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   Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side effects not seen in phase 3 trials, including thrombosis with thrombocytopenia syndrome (TTS), a rare condition resembling heparin-induced thrombocytopenia (HIT), have been observed. This study demonstrates that all three adenoviruses deployed as vaccination vectors versus SARS-CoV-2 bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of HIT. We have determined the structure of the ChAdOx1 viral vector and used it in state-of-the-art computational simulations to demonstrate an electrostatic interaction mechanism with PF4, which was confirmed experimentally by surface plasmon resonance. These data confirm that PF4 is capable of forming stable complexes with clinically relevant adenoviruses, an important step in unraveling the mechanisms underlying TTS. 

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2. Making/Unmaking with Metaphors: Generative Co-design with People Living with Chronic Pain

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3. Lasing with multimode guided waves with exceptional degeneracy

   https://doi.org/10.1117/12.2634283  

   Mealy, Tarek; Herrero Parareda, Albert; Furman, Nathaniel; Nikzamir, Alireza; Capolino, Filippo (October 2022, Proceedings Volume PC12196, Active Photonic Platforms 2022; PC121961M (2022))

   Subramania, Ganapathi S.; Foteinopoulou, Stavroula (Ed.)

   We will discuss two kinds of exceptional points of degeneracy in waveguides and their respective application in lasers. Such exceptional points occur in waveguides with balanced loss and gain (e.g., PT symmetry), and in waveguides without loss and gain (e.g., periodic Si waveguides). Waveguides with such exceptional points have a strong degeneracy of their wavenumbers and polarization states that enables specific wave physics, only found in these degenerate systems. We will discuss advantages and disadvantages of both concepts to conceive laser regimes, related to high power, high spectral purity, high efficiency, etc, and show some realistic designs involving Si ridge waveguides. 

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4. Plant phenotyping with limited annotation: Doing more with less

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5. Learning Environments Designed for and With Learners with Disabilities

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