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Title: The importance of microtubule-dependent tension in accurate chromosome segregation
Accurate chromosome segregation is vital for cell and organismal viability. The mitotic spindle, a bipolar macromolecular machine composed largely of dynamic microtubules, is responsible for chromosome segregation during each cell replication cycle. Prior to anaphase, a bipolar metaphase spindle must be formed in which each pair of chromatids is attached to microtubules from opposite spindle poles. In this bipolar configuration pulling forces from the dynamic microtubules can generate tension across the sister kinetochores. The tension status acts as a signal that can destabilize aberrant kinetochore-microtubule attachments and reinforces correct, bipolar connections. Historically it has been challenging to isolate the specific role of tension in mitotic processes due to the interdependency of attachment and tension status at kinetochores. Recent technical and experimental advances have revealed new insights into how tension functions during mitosis. Here we summarize the evidence that tension serves as a biophysical signal that unifies multiple aspects of kinetochore and centromere function to ensure accurate chromosome segregation.  more » « less
Award ID(s):
1846262
PAR ID:
10490149
Author(s) / Creator(s):
;
Publisher / Repository:
Frontiers Media SA
Date Published:
Journal Name:
Frontiers in Cell and Developmental Biology
Volume:
11
ISSN:
2296-634X
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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