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Title: Soft implantable printed bioelectronic system for wireless continuous monitoring of restenosis
Atherosclerosis is a prominent cause of coronary artery disease and broader cardiovascular diseases, the leading cause of death worldwide. Angioplasty and stenting is a common treatment, but in-stent restenosis, where the artery re-narrows, is a frequent complication. Restenosis is detected through invasive procedures and is not currently monitored frequently for patients. Here, we report an implantable vascular bioelectronic device using a newly developed miniaturized strain sensor via microneedle printing methods. A capillary-based printing system achieves high-resolution patterning of a soft, capacitive strain sensor. Ink and printing parameters are evaluated to create a fully printed sensor, while sensor design and sensing mechanism are studied to enhance sensitivity and minimize sensor size. The sensor is integrated with a wireless vascular stent, offering a biocompatible, battery-free, wireless monitoring system compatible with conventional catheterization procedures. The vascular sensing system is demonstrated in an artery model for monitoring restenosis progression. Collectively, the artery implantable bioelectronic system shows the potential for wireless, real-time monitoring of various cardiovascular diseases and stent-integrated sensing/treatments.  more » « less
Award ID(s):
2152638
PAR ID:
10494898
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Publisher / Repository:
Biosensors and Bioelectronics
Date Published:
Journal Name:
Biosensors and Bioelectronics
Volume:
241
Issue:
C
ISSN:
0956-5663
Page Range / eLocation ID:
115650
Subject(s) / Keyword(s):
Biosensors Printed sensors Soft sensors Vascular electronics
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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