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1. The roles of inflammation, affect, and interoception in predicting social perception

   https://doi.org/10.1016/j.bbi.2023.05.011  

   Feldman, Mallory J.; Jolink, Tatum A.; Alvarez, Gabriella M.; Fendinger, Nicholas J.; Gaudier-Diaz, Monica M.; Lindquist, Kristen A.; Muscatell, Keely A. (August 2023, Brain, Behavior, and Immunity)

   “Sickness behavior” is an orchestrated suite of symptoms that commonly occur in the context of inflammation, and is characterized by changes in affect, social experience, and behavior. However, recent evidence suggests that inflammation may not always produce the same set of sickness behavior (e.g., fatigue, anhedonia, and social withdrawal). Rather, inflammation may be linked with different behavior across contexts and/or across in- dividuals, though research in this area is under-developed to-date. In the present study (n = 30), we evaluated the influence of affective context and individual differences in difficulty detecting bodily sensations (i.e., interoceptive difficulty) on social perception following an inflammatory challenge. Inflammation was induced using the influenza vaccine and inflammatory reactivity was operationalized as changes in circulating levels of interleukin-6 (IL-6) before the vaccine and approximately 24 h later. Twenty-four hours after administration of the influenza vaccine, we manipulated affective context using a well-validated affect misattribution task in which participants made trustworthiness judgments of individuals with neutral facial expressions following the rapid presentation of “prime” images that were positive or negative in affective content. Interoceptive difficulty was measured at baseline using a validated self-report measure. Results revealed significant interactions between inflammatory reactivity to the influenza vaccine and affective context on social perception. Specifically, in- dividuals with greater inflammatory reactivity were more biased by affective context when judging the trust- worthiness of neutral faces. In addition, interoceptive difficulty and affective context interacted to predict social perception such that individuals with greater interoceptive difficulty were more biased by affective context in these judgments. In sum, we provide some of the first evidence that inflammation may amplify the saliency of affective cues during social decision making. Our findings also replicate prior work linking interoceptive ability to the use of affect-as-information during social perception, but in the novel context of inflammation. 

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2. Oxytocin impairs wound-healing during social isolation but not social living

   https://doi.org/10.1016/j.psyneuen.2025.107445  

   Hammond, Emma; Monari, Patrick; Kilponen, Lila; Chen, Yiru; Auger, Anthony; Marler, Catherine (June 2025, Psychoneuroendocrinology)

   Social isolation hampers immune system function, and the biological mechanisms driving this effect remain understudied. We hypothesized that oxytocin (OT), a key neuropeptide involved in social cognition, is a critical mediator of social context on immune function. In the California mouse (Peromyscus californicus), we examined how female and male immune function is influenced by (1) social isolation from same-sex peers, (2) social peer affiliation, and (3) exogenous OT. We evaluated immune function through wound size progression following a skin biopsy and proinflammatory cytokines in the wound fluid. Unexpectedly, social isolation alone did not influence wound healing, but isolation +OT increased wound size in a dose dependent manner. Wound size progression interacted with sex and OT in socially-housed mice, suggesting that OT increases inflammation in females, while decreasing inflammation in males in a social context-dependent manner. Inflammatory biomarker interleukin-6 (IL-6) mRNA expression correlated with wound size overall, supporting wound healing as an index of inflammatory response. However, isolation +OT mice did not have higher levels of IL-6, suggesting that the mechanism through which isolation +OT influences wound size is not through IL-6 activity. Behaviorally, higher levels of affiliation were negatively associated with wound size, and this effect was diminished by OT treatment. Our results highlight that the anti-inflammatory effects of OT are likely highly dependent on social context. 

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3. Prolonged Release and Functionality of Interleukin-10 Encapsulated within PLA-PEG Nanoparticles

   https://doi.org/10.3390/nano9081074  

   Duncan, Skyla A.; Dixit, Saurabh; Sahu, Rajnish; Martin, David; Baganizi, Dieudonné R.; Nyairo, Elijah; Villinger, Francois; Singh, Shree R.; Dennis, Vida A. (August 2019, Nanomaterials)

   Inflammation, as induced by the presence of cytokines and chemokines, is an integral part of chlamydial infections. The anti-inflammatory cytokine, interleukin (IL)-10, has been reported to efficiently suppress the secretion of inflammatory cytokines triggered by Chlamydia in mouse macrophages. Though IL-10 is employed in clinical applications, its therapeutic usage is limited due to its short half-life. Here, we document the successful encapsulation of IL-10 within the biodegradable polymeric nanoparticles of PLA-PEG (Poly (lactic acid)-Poly (ethylene glycol), to prolong its half-life. Our results show the encapsulated-IL-10 size (~238 nm), zeta potential (−14.2 mV), polydispersity index (0.256), encapsulation efficiency (~77%), and a prolonged slow release pattern up to 60 days. Temperature stability of encapsulated-IL-10 was favorable, demonstrating a heat capacity of up to 89 °C as shown by differential scanning calorimetry analysis. Encapsulated-IL-10 modulated the release of IL-6 and IL-12p40 in stimulated macrophages in a time- and concentration-dependent fashion, and differentially induced SOCS1 and SOCS3 as induced by chlamydial stimulants in macrophages. Our finding offers the tremendous potential for encapsulated-IL-10 not only for chlamydial inflammatory diseases but also biomedical therapeutic applications. 

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4. Understanding the Consequences of Moment-by-Moment Fluctuations in Mood and Social Experience for Paranoid Ideation in Psychotic Disorders

   https://doi.org/10.1093/schizbullopen/sgac064  

   Orth, Ryan D.; Hur, Juyoen; Jacome, Anyela M.; Savage, Christina L. G.; Grogans, Shannon E.; Kim, Young-Ho; Choe, Eun Kyoung; Shackman, Alexander J.; Blanchard, Jack J. (October 2022, Schizophrenia Bulletin Open)

   Abstract Among individuals with psychotic disorders, paranoid ideation is common and associated with increased impairment, decreased quality of life, and a more pessimistic prognosis. Although accumulating research indicates negative affect is a key precipitant of paranoid ideation, the possible protective role of positive affect has not been examined. Further, despite the interpersonal nature of paranoid ideation, there are limited and inconsistent findings regarding how social context, perceptions, and motivation influence paranoid ideation in real-world contexts. In this pilot study, we used smartphone ecological momentary assessment to understand the relevance of hour-by-hour fluctuations in mood and social experience for paranoid ideation in adults with psychotic disorders. Multilevel modeling results indicated that greater negative affect is associated with higher concurrent levels of paranoid ideation and that it is marginally related to elevated levels of future paranoid ideation. In contrast, positive affect was unrelated to momentary experiences of paranoid ideation. More severe momentary paranoid ideation was also associated with an elevated desire to withdraw from social encounters, irrespective of when with familiar or unfamiliar others. These observations underscore the role of negative affect in promoting paranoid ideation and highlight the contribution of paranoid ideation to the motivation to socially withdraw in psychotic disorders. 

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5. The Temporal Relationship Between Ecological Pain and Life-Space Mobility in Older Adults With Knee Osteoarthritis: A Smartwatch-Based Demonstration Study

   https://doi.org/10.2196/19609  

   Mardini, Mamoun T; Nerella, Subhash; Kheirkhahan, Matin; Ranka, Sanjay; Fillingim, Roger B; Hu, Yujie; Corbett, Duane B; Cenko, Erta; Weber, Eric; Rashidi, Parisa; et al (January 2021, JMIR mHealth and uHealth)

   null (Ed.)

   Background Older adults who experience pain are more likely to reduce their community and life-space mobility (ie, the usual range of places in an environment in which a person engages). However, there is significant day-to-day variability in pain experiences that offer unique insights into the consequences on life-space mobility, which are not well understood. This variability is complex and cannot be captured with traditional recall-based pain surveys. As a solution, ecological momentary assessments record repeated pain experiences throughout the day in the natural environment. Objective The aim of this study was to examine the temporal association between ecological momentary assessments of pain and GPS metrics in older adults with symptomatic knee osteoarthritis by using a smartwatch platform called Real-time Online Assessment and Mobility Monitor. Methods Participants (n=19, mean 73.1 years, SD 4.8; female: 13/19, 68%; male: 6/19, 32%) wore a smartwatch for a mean period of 13.16 days (SD 2.94). Participants were prompted in their natural environment about their pain intensity (range 0-10) at random time windows in the morning, afternoon, and evening. GPS coordinates were collected at 15-minute intervals and aggregated each day into excursion, ellipsoid, clustering, and trip frequency features. Pain intensity ratings were averaged across time windows for each day. A random effects model was used to investigate the within and between-person effects. Results The daily mean pain intensities reported by participants ranged between 0 and 8 with 40% reporting intensities ≥2. The within-person associations between pain intensity and GPS features were more likely to be statistically significant than those observed between persons. Within-person pain intensity was significantly associated with excursion size, and others (excursion span, total distance, and ellipse major axis) showed a statistical trend (excursion span: P=.08; total distance: P=.07; ellipse major axis: P=.07). Each point increase in the mean pain intensity was associated with a 3.06 km decrease in excursion size, 2.89 km decrease in excursion span, 5.71 km decrease total distance travelled per day, 31.4 km2 decrease in ellipse area, 0.47 km decrease ellipse minor axis, and 3.64 km decrease in ellipse major axis. While not statistically significant, the point estimates for number of clusters (P=.73), frequency of trips (P=.81), and homestay (P=.15) were positively associated with pain intensity, and entropy (P=.99) was negatively associated with pain intensity. Conclusions In this demonstration study, higher intensity knee pain in older adults was associated with lower life-space mobility. Results demonstrate that a custom-designed smartwatch platform is effective at simultaneously collecting rich information about ecological pain and life-space mobility. Such smart tools are expected to be important for remote health interventions that harness the variability in pain symptoms while understanding their impact on life-space mobility. 

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