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Title: Biocompatible Polyglycidol-based hydrogels for load-bearing tissue engineering
The post-polymerization modification of polyglycidol is of great interest for the synthesis of functional polyether-based polymeric biomaterials. We present a degradable polyglycidol-based hydrogel system using oxime click chemistry by employing a ketone-functionalized and an amino-oxy functionalized branched polyglycidol. Ratio-controlled amino-oxy functionalized species were obtained by controlling the ratio of N-hydroxy phthalimide to the hydroxyl groups attached to the polyether backbone. A similar strategy was utilized to obtain ratio-controlled keto functionalized branched polyglycidols. This unique feature will allow for the tailoring of this branched PEG-like structural motif for the synthesis of novel biomaterials with tailored biochemical and biomechanical properties. The bio-orthogonal nature of this crosslinking reaction makes these hydrogels an attractive option for load-bearing tissue engineering. Our hydrogel synthesis methodology allows for control over the properties of the resulting polymeric network, based upon the ratio between the keto and the amino-oxy functionalities. The potential of these polyether-based networks to serve as a successful delivery platform was assessed by studying their swelling and degradation profiles. Biocompatibility and cytotoxicity of the gels were studied using NIH 3T3 cells. Our preliminary results highlighting the potential of our hydrogels platform will be discussed.  more » « less
Award ID(s):
2200484
PAR ID:
10511283
Author(s) / Creator(s):
;
Corporate Creator(s):
Publisher / Repository:
SciMeetings, A product from ACS Publications
Date Published:
Edition / Version:
2024
Subject(s) / Keyword(s):
ACS Spring 2024
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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