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Title: The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects
Notably, 3D-printed flexible and wearable biosensors have immense potential to interact with the human body noninvasively for the real-time and continuous health monitoring of physiological parameters. This paper comprehensively reviews the progress in 3D-printed wearable biosensors. The review also explores the incorporation of nanocomposites in 3D printing for biosensors. A detailed analysis of various 3D printing processes for fabricating wearable biosensors is reported. Besides this, recent advances in various 3D-printed wearable biosensors platforms such as sweat sensors, glucose sensors, electrocardiography sensors, electroencephalography sensors, tactile sensors, wearable oximeters, tattoo sensors, and respiratory sensors are discussed. Furthermore, the challenges and prospects associated with 3D-printed wearable biosensors are presented. This review is an invaluable resource for engineers, researchers, and healthcare clinicians, providing insights into the advancements and capabilities of 3D printing in the wearable biosensor domain. more »« less
Park, Sehyun; Kim, Hojoong; Kim, Jong-Hoon; Yeo, Woon-Hong(
, Materials)
null
(Ed.)
Recent advances in nanomaterial preparation and printing technologies provide unique opportunities to develop flexible hybrid electronics (FHE) for various healthcare applications. Unlike the costly, multi-step, and error-prone cleanroom-based nano-microfabrication, the printing of nanomaterials offers advantages, including cost-effectiveness, high-throughput, reliability, and scalability. Here, this review summarizes the most up-to-date nanomaterials, methods of nanomaterial printing, and system integrations to fabricate advanced FHE in wearable and implantable applications. Detailed strategies to enhance the resolution, uniformity, flexibility, and durability of nanomaterial printing are summarized. We discuss the sensitivity, functionality, and performance of recently reported printed electronics with application areas in wearable sensors, prosthetics, and health monitoring implantable systems. Collectively, the main contribution of this paper is in the summary of the essential requirements of material properties, mechanisms for printed sensors, and electronics.
Li, Yizong; Liu, Yuxuan; Bhuiyan, Shah Rifat Alam; Zhu, Yong; Yao, Shanshan(
, Small Structures)
On‐skin electronics have drawn extensive attention as they revolutionize many aspects of healthcare, motion tracking, rehabilitation, robotics, human–machine interaction, among others. Flexible and stretchable strain sensors represent one of the most explored devices for on‐skin electronics. Many printing techniques have recently emerged showing great promises for manufacturing strain sensors. Herein, it is aimed to provide a timely survey of recent advancements in printed strain sensors for on‐skin electronics. This review starts with an overview of sensing mechanisms for printed strain sensors, followed by a review of various printing techniques employed in fabricating these sensors. The materials, structures, and printing processes of representative strain sensors are discussed in detail for each printing method. Finally, potential applications of printed flexible and stretchable strain sensors are presented focusing on three areas: healthcare, sports performance monitoring, and human–machine interfaces. The review concludes with a discussion of challenges and opportunities for future research.
Triboelectric nanogenerator (TENG) devices are extensively studied as a mechanical energy harvester and self‐powered sensor for wearable electronics and physiological monitoring. However, the conventional TENG fabrication involving assembling steps and using the single property of matrix material suffers from simple devices shape and a single level of mechanical response for sensing and energy harvesting. Here, the printed multimaterial matrix for multilevel mechanical‐responsive TENG with on‐demand reconfiguration of shape is reported. A multimaterial 3D printing approach by using dynamic photomask‐assisted direct ink writing printing together with a two‐stage curing hybrid ink is first developed. Multimaterial structures with location‐specific properties, such as tensile modulus, failure stress, and glass transition temperature for controlled deformation, crack propagation path, and sequential shape memory, are directly printed. The printed multimaterial structure with sequential deformation behavior is used to fabricate a multilevel‐TENG (mTENG) device for multiple level mechanical energy harvesters and sensors. It is demonstrated that the mTENG can be embedded in shoe insoles to achieve both comfortable wearing and motion state monitoring. This work provides a new approach to combine multimaterial 3D printing with TENG devices for functional wearable electronics as energy harvester and sensors.
Du, Xian; Wankhede, Sahil P.; Prasad, Shishir; Shehri, Ali; Morse, Jeffrey; Lakal, Narendra(
, Journal of Materials Chemistry C)
Personalized healthcare (PHC) is a booming sector in the health science domain wherein researchers from diverse technical backgrounds are focusing on the need for remote human health monitoring. PHC employs wearable electronics, viz. group of sensors integrated on a flexible substrate, embedded in the clothes, or attached to the body via adhesive. PHC wearable flexible electronics (FE) offer numerous advantages including being versatile, comfortable, lightweight, flexible, and body conformable. However, finding the appropriate mass manufacturing technologies for these PHC devices is still a challenge. It needs an understanding of the physics, performance, and applications of printing technologies for PHC wearables, ink preparation, and bio-compatible device fabrication. Moreover, the detailed study of the operating principle, ink, and substrate materials of the printing technologies such as inkjet printing will help identify the opportunities and emerging challenges of applying them in manufacturing of PHC wearable devices. In this article, we attempt to bridge this gap by reviewing the printing technologies in the PHC domain, especially inkjet printing in depth. This article presents a brief review of the state-of-the-art wearable devices made by various printing methods and their applications in PHC. It focuses on the evaluation and application of these printing technologies for PHC wearable FE devices, along with advancements in ink preparation and bio-compatible device fabrication. The performance of inkjet, screen, gravure, and flexography printing, as well as the inks and substrates, are comparatively analyzed to aid PHC wearable sensor design, research, fabrication, and mass manufacturing. Moreover, it identifies the application of the emerging mass-customizable printing technologies, such as inkjet printing, in the manufacturing of PHC wearable devices, and reviews the printing principles, drop generation mechanisms, ink formulations, ink-substrate interactions, and matching strategies for printing wearable devices on stretchable substrates. Four surface matching strategies are extracted from literature for the guidance of inkjet printing of PHC stretchable electronics. The electro-mechanical performance of the PHC FE devices printed using four surface matching strategies is comparatively evaluated. Further, the article extends its review by describing the scalable integration of PHC devices and finally presents the future directions of research in printing technologies for PHC wearable devices.
Park, Sung Hyun; Su, Ruitao; Jeong, Jaewoo; Guo, Shuang‐Zhuang; Qiu, Kaiyan; Joung, Daeha; Meng, Fanben; McAlpine, Michael C.(
, Advanced Materials)
Abstract
Extrusion‐based 3D printing, an emerging technology, has been previously used in the comprehensive fabrication of light‐emitting diodes using various functional inks, without cleanrooms or conventional microfabrication techniques. Here, polymer‐based photodetectors exhibiting high performance are fully 3D printed and thoroughly characterized. A semiconducting polymer ink is printed and optimized for the active layer of the photodetector, achieving an external quantum efficiency of 25.3%, which is comparable to that of microfabricated counterparts and yet created solely via a one‐pot custom built 3D‐printing tool housed under ambient conditions. The devices are integrated into image sensing arrays with high sensitivity and wide field of view, by 3D printing interconnected photodetectors directly on flexible substrates and hemispherical surfaces. This approach is further extended to create integrated multifunctional devices consisting of optically coupled photodetectors and light‐emitting diodes, demonstrating for the first time the multifunctional integration of multiple semiconducting device types which are fully 3D printed on a single platform. The 3D‐printed optoelectronic devices are made without conventional microfabrication facilities, allowing for flexibility in the design and manufacturing of next‐generation wearable and 3D‐structured optoelectronics, and validating the potential of 3D printing to achieve high‐performance integrated active electronic materials and devices.
Parupelli, Santosh Kumar, and Desai, Salil. The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects. Retrieved from https://par.nsf.gov/biblio/10514911. Bioengineering 11.1 Web. doi:10.3390/bioengineering11010032.
Parupelli, Santosh Kumar, & Desai, Salil. The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects. Bioengineering, 11 (1). Retrieved from https://par.nsf.gov/biblio/10514911. https://doi.org/10.3390/bioengineering11010032
@article{osti_10514911,
place = {Country unknown/Code not available},
title = {The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects},
url = {https://par.nsf.gov/biblio/10514911},
DOI = {10.3390/bioengineering11010032},
abstractNote = {Notably, 3D-printed flexible and wearable biosensors have immense potential to interact with the human body noninvasively for the real-time and continuous health monitoring of physiological parameters. This paper comprehensively reviews the progress in 3D-printed wearable biosensors. The review also explores the incorporation of nanocomposites in 3D printing for biosensors. A detailed analysis of various 3D printing processes for fabricating wearable biosensors is reported. Besides this, recent advances in various 3D-printed wearable biosensors platforms such as sweat sensors, glucose sensors, electrocardiography sensors, electroencephalography sensors, tactile sensors, wearable oximeters, tattoo sensors, and respiratory sensors are discussed. Furthermore, the challenges and prospects associated with 3D-printed wearable biosensors are presented. This review is an invaluable resource for engineers, researchers, and healthcare clinicians, providing insights into the advancements and capabilities of 3D printing in the wearable biosensor domain.},
journal = {Bioengineering},
volume = {11},
number = {1},
publisher = {MDPI},
author = {Parupelli, Santosh Kumar and Desai, Salil},
}
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