Abstract The transverse momentum ($$p_{\textrm{T}}$$ ) differential production cross section of the promptly produced charm-strange baryon$$\mathrm {\Xi _{c}^{0}}$$ (and its charge conjugate$$\overline{\mathrm {\Xi _{c}^{0}}}$$ ) is measured at midrapidity via its hadronic decay into$$\mathrm{\pi ^{+}}\Xi ^{-}$$ in p–Pb collisions at a centre-of-mass energy per nucleon–nucleon collision$$\sqrt{s_{\textrm{NN}}}~=~5.02$$ TeV with the ALICE detector at the LHC. The$$\mathrm {\Xi _{c}^{0}}$$ nuclear modification factor ($$R_{\textrm{pPb}}$$ ), calculated from the cross sections in pp and p–Pb collisions, is presented and compared with the$$R_{\textrm{pPb}}$$ of$$\mathrm {\Lambda _{c}^{+}}$$ baryons. The ratios between the$$p_{\textrm{T}}$$ -differential production cross section of$$\mathrm {\Xi _{c}^{0}}$$ baryons and those of$$\mathrm {D^0}$$ mesons and$$\mathrm {\Lambda _{c}^{+}}$$ baryons are also reported and compared with results at forward and backward rapidity from the LHCb Collaboration. The measurements of the production cross section of prompt$$\Xi ^0_\textrm{c}$$ baryons are compared with a model based on perturbative QCD calculations of charm-quark production cross sections, which includes only cold nuclear matter effects in p–Pb collisions, and underestimates the measurement by a factor of about 50. This discrepancy is reduced when the data is compared with a model that includes string formation beyond leading-colour approximation or in which hadronisation is implemented via quark coalescence. The$$p_{\textrm{T}}$$ -integrated cross section of prompt$$\Xi ^0_\textrm{c}$$ -baryon production at midrapidity extrapolated down to$$p_{\textrm{T}}$$ = 0 is also reported. These measurements offer insights and constraints for theoretical calculations of the hadronisation process. Additionally, they provide inputs for the calculation of the charm production cross section in p–Pb collisions at midrapidity.
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COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator
Abstract Silent hypoxemia, or "happy hypoxia", is a puzzling phenomenon in which patients who have contracted COVID-19 exhibit very low oxygen saturation ( < 80%) but do not experience discomfort in breathing. The mechanism by which this blunted response to hypoxia occurs is unknown. We have previously shown that a computational model of the respiratory neural network (Diekman et al. in J Neurophysiol 118(4):2194–2215, 2017) can be used to test hypotheses focused on changes in chemosensory inputs to the central pattern generator (CPG). We hypothesize that altered chemosensory function at the level of the carotid bodies and/or thenucleus tractus solitariiare responsible for the blunted response to hypoxia. Here, we use our model to explore this hypothesis by altering the properties of the gain function representing oxygen sensing inputs to the CPG. We then vary other parameters in the model and show that oxygen carrying capacity is the most salient factor for producing silent hypoxemia. We call for clinicians to measure hematocrit as a clinical index of altered physiology in response to COVID-19 infection.
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- PAR ID:
- 10517697
- Publisher / Repository:
- Springer
- Date Published:
- Journal Name:
- Biological Cybernetics
- ISSN:
- 1432-0770
- Subject(s) / Keyword(s):
- Silent hypoxemia Breathing control Central pattern generator Computational modeling COVID-19 Polycythemia Sensory feedback
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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