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ABSTRACT ObjectiveNeighborhood perceptions are associated with physical and mental health outcomes; however, the biological associates of this relationship remain to be fully understood. Here, we evaluate the relationship between neighborhood perceptions and amygdala activity and connectivity with salience network (i.e., insula, anterior cingulate, thalamus) nodes. MethodsForty-eight older adults (mean age = 68 [7] years, 52% female, 47% non-Hispanic Black, 2% Hispanic) without dementia or depression completed the Perceptions of Neighborhood Environment Scale. Lower scores indicated less favorable perceptions of aesthetic quality, walking environment, availability of healthy food, safety, violence (i.e., more perceived violence), social cohesion, and participation in activities with neighbors. Participants separately underwent resting-state functional magnetic resonance imaging. ResultsLess favorable perceived safety (β= −0.33,pFDR= .04) and participation in activities with neighbors (β= −0.35,pFDR= .02) were associated with higher left amygdala activity, independent of covariates including psychosocial factors. Less favorable safety perceptions were also associated with enhanced left amygdala functional connectivity with the bilateral insular cortices and the left anterior insula (β= −0.34,pFDR= .04). Less favorable perceived social cohesion was associated with enhanced left amygdala functional connectivity with the right thalamus (β =−0.42,pFDR= .04), and less favorable perceptions about healthy food availability were associated with enhanced left amygdala functional connectivity with the bilateral anterior insula (right:β= −0.39,pFDR= .04; left:β= −0.42,pFDR= .02) and anterior cingulate gyrus (β= −0.37,pFDR= .04). ConclusionsTaken together, our findings document relationships between select neighborhood perceptions and amygdala activity as well as connectivity with salience network nodes; if confirmed, targeted community-level interventions and existing community strengths may promote brain-behavior relationships.
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High Levels of Triggering Receptor Expressed in Myeloid Cells-Like Transcript-1 Positive, but Not Glycoprotein 1b+, Microparticles Are Associated With Poor Outcomes in Acute Respiratory Distress Syndrome
OBJECTIVES:To identify triggering receptor expressed in myeloid cells-like transcript-1 positive (TLT-1+) microparticles (MPs) and evaluate if their presence is associated with clinical outcomes and/or disease severity in acute respiratory distress syndrome (ARDS). DESIGN:Retrospective cohort study. SETTING:ARDS Network clinical trials. PATIENTS:A total of 564 patients were diagnosed with ARDS. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Using flow cytometry, we demonstrated the presence of TLT-1+platelet-derived microparticles (PMP) that bind fibrinogen in plasma samples from fresh donors. We retrospectively quantified TLT-1, glycoprotein (Gp) 1b, or αIIbβIIIaimmunopositive microparticles in plasma samples from patients with ARDS enrolled in the ARMA, KARMA, and LARMA (Studies 01 and 03 lower versus higher tidal volume, ketoconazole treatment, and lisofylline treatment Clincial Trials) ARDS Network clinical trials and evaluated the relationship between these measures and clinical outcomes. No associations were found between Gp1b+MPs and clinical outcomes for any of the cohorts. When stratified by quartile, associations were found for survival, ventilation-free breathing, and thrombocytopenia with αIIbβIIIa+and TLT-1+MPs (χ2p< 0.001). Notably, 63 of 64 patients in this study who failed to achieve unassisted breathing had TLT+PMP in the 75th percentile. In all three cohorts, patients whose TLT+MP counts were higher than the median had higher Acute Physiology and Chronic Health Evaluation III scores, were more likely to present with thrombocytopenia and were 3.7 times (p< 0.001) more likely to die than patients with lower TLT+PMP after adjusting for other risk factors. CONCLUSIONS:Although both αIIbβIIIa+and TLT+microparticles (αIIbβIIIa, TLT-1) were associated with mortality, TLT-1+MPs demonstrated stronger correlations with Acute Physiology and Chronic Health Evaluation III scores, unassisted breathing, and multiple system organ failure. These findings warrant further exploration of the mechanistic role of TLT-1+PMP in ARDS or acute lung injury progression.
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- Award ID(s):
- 2244091
- PAR ID:
- 10527447
- Publisher / Repository:
- Society of Critical Care Medicine
- Date Published:
- Journal Name:
- Critical Care Explorations
- Volume:
- 6
- Issue:
- 7
- ISSN:
- 2639-8028
- Page Range / eLocation ID:
- e1108
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1097/CCE.0000000000001108
