Abstract Dysphagia or difficulty swallowing is caused by the failure of neurological pathways to properly activate swallowing muscles. Current electromyography (EMG) systems for dysphagia monitoring are bulky and rigid, limiting their potential for long‐term and unobtrusive use. To address this, a machine learning‐assisted wearable EMG system is presented, utilizing self‐adhesive, skin‐conformal, semi‐transparent, and robust ionic gel electrodes. The presented electrodes possess good conductivity, superior skin contact, and good transmittance, ensuring high‐fidelity EMG sensing without impeding daily activities. Moreover, the optimized material and structural designs ensure wearing comfort and conformable skin‐electrode contact, allowing for long‐term monitoring with high accuracy. Machine learning and mel‐frequency cepstral coefficient techniques are employed to classify swallowing events based on food types and volumes. Through an analysis of electrode placement on the chin and neck, the proposed system is able to effectively distinguish between different food types and water volumes using a small number of channels, making it suitable for continuous dysphagia monitoring. This work represents an advancement in machine learning assisted EMG systems for the classification and regression of swallowing events, paving the way for more efficient, unobtrusive, and long‐term dysphagia monitoring systems.
more »
« less
Dynamic quantitative phase microscopy: a single-shot approach using geometric phase interferometry
Abstract There is a significant gap in cost-effective quantitative phase microscopy (QPM) systems for studying dynamic cellular processes while maintaining accuracy for long-term cellular monitoring. Current QPM systems often rely on complex and expensive voltage-controllable components like Spatial Light Modulators or two-beam interferometry. To address this, we introduce a QPM system optimized for time-varying phase samples using azobenzene liquid crystal as a Zernike filter with a polarization-sensing camera. This system operates without input voltage or moving components, reducing complexity and cost. Optimized for gentle illumination to minimize phototoxicity, it achieves a 1 Hz frame rate for prolonged monitoring. The system demonstrated accuracy with a maximum standard deviation of ±42 nm and low noise fluctuations of ±2.5 nm. Designed for simplicity and single-shot operations, our QPM system is efficient, robust, and precisely calibrated for reliable measurements. Using inexpensive optical components, it offers an economical solution for long-term, noninvasive biological monitoring and research applications.
more »
« less
- Award ID(s):
- 2047592
- PAR ID:
- 10528966
- Publisher / Repository:
- Nature Publishing Group
- Date Published:
- Journal Name:
- Communications Physics
- Volume:
- 7
- Issue:
- 1
- ISSN:
- 2399-3650
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit fluorescence microscopy’s utility. Recently, it has been shown that artificial intelligence (AI) can transform one form of contrast into another. We present phase imaging with computational specificity (PICS), a combination of quantitative phase imaging and AI, which provides information about unlabeled live cells with high specificity. Our imaging system allows for automatic training, while inference is built into the acquisition software and runs in real-time. Applying the computed fluorescence maps back to the quantitative phase imaging (QPI) data, we measured the growth of both nuclei and cytoplasm independently, over many days, without loss of viability. Using a QPI method that suppresses multiple scattering, we measured the dry mass content of individual cell nuclei within spheroids. In its current implementation, PICS offers a versatile quantitative technique for continuous simultaneous monitoring of individual cellular components in biological applications where long-term label-free imaging is desirable.more » « less
-
Miniaturization of the neuromodulation system is important for non-invasive or sub-invasive optogenetic application. This work presents an optimized wireless power transfer (WPT) system integrated with an on-chip rectification circuitry and an off-chip stimulation circuitry for optogenetic stimulation of freely moving rodents. The proposed WPT system is built using parallel transmitter (TX) coils on printed circuit board (PCB) and wire-wound based receiver (RX) coil followed by a seven-stage voltage doubler and a low dropout regulator (LDO) circuit designed in 180 nm standard Complementary Metal Oxide Semiconductor (CMOS) process. A pulse stimulation is used to stimulate the neurons which is generated using a commercially available off-the-shelf (COTS) components based oscillator circuit. The intensity of the stimulation is controlled by using a COTS based LED driver circuit which controls the current through the μ LED. The total dimension of the RX coil is 8 mm × 3.4 mm. The maximum power transfer efficiency (PTE) of the proposed WPT system is ∼ 35% and the power conversion efficiency (PCE) of the rectifier is 52%. The proposed system with reconfigurable stimulation frequency is suitable for exciting different brain areas for long-term health monitoring.more » « less
-
Abstract While preventive maintenance is crucial in wind turbine operation, conventional condition monitoring systems face limitations in terms of cost and complexity when compared to innovative signal processing techniques and artificial intelligence. In this paper, a cascading deep learning framework is proposed for the monitoring of generator winding conditions, specifically to promptly detect and identify inter-turn short circuit faults and estimate their severity in real time. This framework encompasses the processing of high-resolution current signal samples, coupled with the extraction of current signal features in both time and frequency domains, achieved through discrete wavelet transform. By leveraging long short-term memory recurrent neural networks, our aim is to establish a cost-efficient and reliable condition monitoring system for wind turbine generators. Numeral experiments show an over 97% accuracy for fault diagnosis and severity estimation. More specifically, with the intrinsic feature provided by wavelet transform, the faults can be 100% identified by the diagnosis model.more » « less
-
We have developed a low-cost approach for accurately measuring short-term vertical motions of the seafloor and maintaining a continuous long-term record of seafloor pressure without the requirement for costly ship time. We equipped the University of Hawai‘i Liquid Robotics Wave Glider with an integrated acoustic telemetry package, a dual-frequency geodetic-grade global positioning system (GPS) receiver, meteorological pressure sensor, processing unit, and cellular communications. The Wave Glider interrogates high accuracy pressure sensors on the seafloor to retrieve their pressure and temperature data. We correct the seafloor pressure measurements using sea surface kinematic GPS location and atmospheric pressure data collected by the Wave Glider payload. By combining the concurrent seafloor and sea surface observations, we demonstrate the capability to provide timely, continuous, and high-accuracy estimation and monitoring of centimeter-scale vertical seafloor motions.more » « less
An official website of the United States government
