We develop an analytical framework to appropriately model and adequately analyze A/B tests in presence of nonparametric nonstationarities in the targeted business metrics. A/B tests, also known as online randomized controlled experiments, have been used at scale by data-driven enterprises to guide decisions and test innovative ideas to improve core business metrics. Meanwhile, nonstationarities, such as the time-of-day effect and the day-of-week effect, can often arise nonparametrically in key business metrics involving purchases, revenue, conversions, customer experiences, and so on. First, we develop a generic nonparametric stochastic model to capture nonstationarities in A/B test experiments, where each sample represents a visit or action associated with a time label. We build a practically relevant limiting regime to facilitate analyzing large-sample estimator performances under nonparametric nonstationarities. Second, we show that ignoring or inadequately addressing nonstationarities can cause standard A/B test estimators to have suboptimal variance and nonvanishing bias, therefore leading to loss of statistical efficiency and accuracy. We provide a new estimator that views time as a continuous strata and performs poststratification with a data-dependent number of stratification levels. Without making parametric assumptions, we prove a central limit theorem for the proposed estimator and show that the estimator attains the best achievable asymptotic variance and is asymptotically unbiased. Third, we propose a time-grouped randomization that is designed to balance treatment and control assignments at granular time scales. We show that when the time-grouped randomization is integrated to standard experimental designs to generate experiment data, simple A/B test estimators can achieve asymptotically optimal variance. A brief account of numerical experiments are conducted to illustrate the analysis. This paper was accepted by Baris Ata, stochastic models and simulation. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022.01205 .
more »
« less
Semiparametric Efficient Inference in Adaptive Experiments
We consider the problem of efficient inference of the Average Treatment Effect in a sequential experiment where the policy governing the assignment of subjects to treatment or control can change over time. We first provide a central limit theorem for the Adaptive Augmented Inverse-Probability Weighted estimator, which is semiparametric efficient, under weaker assumptions than those previously made in the literature. This central limit theorem enables efficient inference at fixed sample sizes. We then consider a sequential inference setting, deriving both asymptotic and nonasymptotic confidence sequences that are considerably tighter than previous methods. These anytime-valid methods enable inference under data-dependent stopping times (sample sizes). Additionally, we use propensity score truncation techniques from the recent off-policy estimation literature to reduce the finite sample variance of our estimator without affecting the asymptotic variance. Empirical results demonstrate that our methods yield narrower confidence sequences than those previously developed in the literature while maintaining time-uniform error control.
more »
« less
- PAR ID:
- 10529412
- Publisher / Repository:
- Proceedings of Machine Learning Research
- Date Published:
- Volume:
- 236
- Format(s):
- Medium: X
- Location:
- Causal Learning and Reasoning, 2024
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Abstract We consider the construction of confidence bands for survival curves under the outcome‐dependent stratified sampling. A main challenge of this design is that data are a biased dependent sample due to stratification and sampling without replacement. Most literature on regression approximates this design by Bernoulli sampling but variance is generally overestimated. Even with this approximation, the limiting distribution of the inverse probability weighted Kaplan–Meier estimator involves a general Gaussian process, and hence quantiles of its supremum is not analytically available. In this paper, we provide a rigorous asymptotic theory for the weighted Kaplan–Meier estimator accounting for dependence in the sample. We propose the novel hybrid method to both simulate and bootstrap parts of the limiting process to compute confidence bands with asymptotically correct coverage probability. Simulation study indicates that the proposed bands are appropriate for practical use. A Wilms tumor example is presented.more » « less
-
When faced with sequential decision-making problems, it is often useful to be able to predict what would happen if decisions were made using a new policy. Those predictions must often be based on data collected under some previously used decision-making rule. Many previous methods enable such off-policy (or counterfactual) estimation of the expected value of a performance measure called the return. In this paper, we take the first steps towards a universal off-policy estimator (UnO)—one that provides off-policy estimates and high-confidence bounds for any parameter of the return distribution. We use UnO for estimating and simultaneously bounding the mean, variance, quantiles/median, inter-quantile range, CVaR, and the entire cumulative distribution of returns. Finally, we also discuss UnO’s applicability in various settings, including fully observable, partially observable (i.e., with unobserved confounders), Markovian, non-Markovian, stationary, smoothly non-stationary, and discrete distribution shifts.more » « less
-
Abstract Censored survival data are common in clinical trial studies. We propose a unified framework for sensitivity analysis to censoring at random in survival data using multiple imputation and martingale, called SMIM. The proposed framework adopts the δ‐adjusted and control‐based models, indexed by the sensitivity parameter, entailing censoring at random and a wide collection of censoring not at random assumptions. Also, it targets a broad class of treatment effect estimands defined as functionals of treatment‐specific survival functions, taking into account missing data due to censoring. Multiple imputation facilitates the use of simple full‐sample estimation; however, the standard Rubin's combining rule may overestimate the variance for inference in the sensitivity analysis framework. We decompose the multiple imputation estimator into a martingale series based on the sequential construction of the estimator and propose the wild bootstrap inference by resampling the martingale series. The new bootstrap inference has a theoretical guarantee for consistency and is computationally efficient compared to the nonparametric bootstrap counterpart. We evaluate the finite‐sample performance of the proposed SMIM through simulation and an application on an HIV clinical trial.more » « less
-
Summary Since the introduction of fiducial inference by Fisher in the 1930s, its application has been largely confined to relatively simple, parametric problems. In this paper, we present what might be the first time fiducial inference is systematically applied to estimation of a nonparametric survival function under right censoring. We find that the resulting fiducial distribution gives rise to surprisingly good statistical procedures applicable to both one-sample and two-sample problems. In particular, we use the fiducial distribution of a survival function to construct pointwise and curvewise confidence intervals for the survival function, and propose tests based on the curvewise confidence interval. We establish a functional Bernstein–von Mises theorem, and perform thorough simulation studies in scenarios with different levels of censoring. The proposed fiducial-based confidence intervals maintain coverage in situations where asymptotic methods often have substantial coverage problems. Furthermore, the average length of the proposed confidence intervals is often shorter than the length of confidence intervals for competing methods that maintain coverage. Finally, the proposed fiducial test is more powerful than various types of log-rank tests and sup log-rank tests in some scenarios. We illustrate the proposed fiducial test by comparing chemotherapy against chemotherapy combined with radiotherapy, using data from the treatment of locally unresectable gastric cancer.more » « less
An official website of the United States government

