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Title: Achieving tendon enthesis regeneration across length scales
Surgical reattachment of tendon to bone is a clinical challenge, with unacceptably high retear rates in the early period after repair. A primary reason for these repeated tears is that the multiscale toughening mechanisms found at the healthy tendon enthesis are not regenerated during tendon -to -bone healing. The need for technologies to improve these outcomes is pressing, and the tissue engineering community has responded with many advances that hold promise for eventually regenerating the multiscale tissue interface that transfers loads between the two dissimilar materials, tendon, and bone. This review provides an assessment of the state of these approaches, with the aim of identifying a critical agenda for future progress.  more » « less
Award ID(s):
2219142 2105150
PAR ID:
10532503
Author(s) / Creator(s):
; ;
Publisher / Repository:
Elsevier
Date Published:
Journal Name:
Current Opinion in Biomedical Engineering
ISSN:
2468-4511
Page Range / eLocation ID:
100547
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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