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This content will become publicly available on August 10, 2025

Title: An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration
Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The Drosophila border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found that a significant number of ribosome biogenesis genes are differentially expressed from early to late migration stages. Here, we performed a small-scale RNAi screen of a subset of these ribosome genes. Knockdown of seven genes disrupted border cell migration, thus revealing a role for ribosome biogenesis genes in regulating collective cell migration.  more » « less
Award ID(s):
2027617
PAR ID:
10533012
Author(s) / Creator(s):
;
Publisher / Repository:
microPublication Biology
Date Published:
Volume:
2024
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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