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   https://doi.org/10.3390/jcs2010009  

   Khan, Arafat; Venkataraman, Satchi; Miller, Ian (March 2018, Journal of Composites Science)
2. Physical Biology of Axonal Damage

   https://doi.org/10.3389/fncel.2018.00144  

   de Rooij, Rijk; Kuhl, Ellen (June 2018, Frontiers in Cellular Neuroscience)
3. Metabolite Damage and Damage Control in a Minimal Genome

   https://doi.org/10.1128/mbio.01630-22  

   Haas, Drago; Thamm, Antje M.; Sun, Jiayi; Huang, Lili; Sun, Lijie; Beaudoin, Guillaume A.; Wise, Kim S.; Lerma-Ortiz, Claudia; Bruner, Steven D.; Breuer, Marian; et al (July 2022, mBio)

   Johnson, Michael David (Ed.)

   ABSTRACT Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimentally validated, including 5-formyltetrahydrofolate cycloligase, coenzyme A (CoA) disulfide reductase, and certain hydrolases. Furthermore, we discovered that an enigmatic YqeK hydrolase domain fused to NadD has a novel proofreading function in NAD synthesis and could double as a MutT-like sanitizing enzyme for the nucleotide pool. Finally, we combined metabolomics and cheminformatics approaches to extend the core metabolic map of JCVI-Syn3A to include promiscuous enzymatic reactions and spontaneous side reactions. This extension revealed that several key metabolite damage control systems remain to be identified in JCVI-Syn3A, such as that for methylglyoxal. IMPORTANCE Metabolite damage and repair mechanisms are being increasingly recognized. We present here compelling genetic and biochemical evidence for the universal importance of these mechanisms by demonstrating that stripping a genome down to its barest essentials leaves metabolite damage control systems in place. Furthermore, our metabolomic and cheminformatic results point to the existence of a network of metabolite damage and damage control reactions that extends far beyond the corners of it that have been characterized so far. In sum, there can be little room left to doubt that metabolite damage and the systems that counter it are mainstream metabolic processes that cannot be separated from life itself. 

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4. Prediction of Damage Initiation and Simulation of Damage Propagation in 3D Woven Composites during Processing

   Kuksenko, D.; Drach, B; Tsukrov, I. (October 2017, Proceedings of the American Society for Composites Technical Conference)

   Some configurations of 3D woven composites are known to be susceptible to processing induced damage in the form of microcracks that develop in the polymer matrix during curing. The microcracking is believed to originate from high residual stresses that develop due to a significant mismatch in the coefficients of thermal expansion between the constituent materials. In this paper, we investigate the applicability of several commonly used stress-based failure criteria for glassy polymers – the von Mises, the Bauwens (Drucker-Prager), the parabolic stress, and the dilatational strain energy density. We study the microcracking phenomenon on the example of the one-to-one orthogonal configuration of the epoxy matrix/carbon fiber 3D woven composites. This configuration is characterized by the high level of the throughthickness reinforcement which appears to exacerbate the matrix damage. The investigation is based on a high-fidelity mesoscale finite element model of an orthogonally reinforced 3D woven composite. We simulate the material’s response to the uniform temperature drop from the curing to room temperature and compare the results of the simulation with the X-ray computed microtomography. We conclude that the curing induced matrix failure is well predicted by the parabolic stress criterion with a proper choice of the material constants. Initiation and propagation of this failure are simulated via sequential deactivation of the elements exceeding the allowable equivalent stress. 

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5. Progressive microscopic damage associated with fault growth: MICROSCOPIC DAMAGE AND FAULT GROWTH

   https://doi.org/10.1029/2012GL052487  

   Tamarkin, T.; Ougier-Simonin, A.; Zhu, Wenlu (August 2012, Geophysical Research Letters)