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Title: SARS-CoV-2 Resistance to Small Molecule Inhibitors
Abstract Purpose of the ReviewSARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern (VOCs), affecting transmissibility, illness severity, and the effectiveness of antiviral drugs. Continuous monitoring and research are crucial to comprehend variant behavior and develop effective response strategies, including identifying mutations that may affect current drug therapies. Recent FindingsAntiviral therapies such as Nirmatrelvir and Ensitrelvir focus on inhibiting 3CLpro, whereas Remdesivir, Favipiravir, and Molnupiravir target nsp12, thereby reducing the viral load. However, the emergence of resistant mutations in 3CLpro and nsp12 could impact the efficiency of these small molecule drug therapeutics. SummaryThis manuscript summarizes mutations in 3CLpro and nsp12, which could potentially reduce the efficacy of drugs. Additionally, it encapsulates recent advancements in small molecule antivirals targeting SARS-CoV-2 viral proteins, including their potential for developing resistance against emerging variants.  more » « less
Award ID(s):
2122158
PAR ID:
10540262
Author(s) / Creator(s):
; ; ;
Publisher / Repository:
Current Clinical Microbiology Reports
Date Published:
Journal Name:
Current Clinical Microbiology Reports
Volume:
11
Issue:
3
ISSN:
2196-5471
Page Range / eLocation ID:
127 to 139
Subject(s) / Keyword(s):
COVID-19 SARS-CoV-2 antibody antiviral drug resistance small-molecule inhibitor
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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