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Title: Organometallic Oxidative Addition Complexes for S -Arylation of Free Cysteines
Development of bioconjugation strategies to efficiently modify biomolecules is of key importance for fundamental and translational scientific studies. Cysteine S-arylation is an approach which is becoming more popular due to generally rapid kinetics and high chemoselectivity, as well as the strong covalently bonded S-aryl linkage created in these processes. Organometallic approaches to cysteine S-arylation have been explored that feature many advantages compared to their more traditional organic counterparts. In this Viewpoint, progress in the use of Au(III) and Pd(II) oxidative addition (OA) complexes for stoichiometric cysteine S-arylation is presented and discussed. A focus is placed on understanding the rapid kinetics of these reactions under mild conditions, as well as the ability to generate biomolecular heterostructures. Potential avenues for further exploration are addressed and usefulness of these methods to the practitioner are emphasized in the discussion.  more » « less
Award ID(s):
2003946
PAR ID:
10542801
Author(s) / Creator(s):
; ;
Publisher / Repository:
ACS Publications
Date Published:
Journal Name:
Bioconjugate Chemistry
Volume:
35
Issue:
7
ISSN:
1043-1802
Page Range / eLocation ID:
883 to 889
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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