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Abstract Understanding treatment effect heterogeneity is vital to many scientific fields because the same treatment may affect different individuals differently. Quantile regression provides a natural framework for modelling such heterogeneity. We propose a new method for inference on heterogeneous quantile treatment effects (HQTE) in the presence of high-dimensional covariates. Our estimator combines an ℓ1-penalised regression adjustment with a quantile-specific bias correction scheme based on rank scores. We study the theoretical properties of this estimator, including weak convergence and semi-parametric efficiency of the estimated HQTE process. We illustrate the finite-sample performance of our approach through simulations and an empirical example, dealing with the differential effect of statin usage for lowering low-density lipoprotein cholesterol levels for the Alzheimer’s disease patients who participated in the UK Biobank study.
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Quantile partially linear additive model for data with dropouts and an application to modeling cognitive decline
The National Alzheimer's Coordinating Center Uniform Data Set includes test results from a battery of cognitive exams. Motivated by the need to model the cognitive ability of low‐performing patients we create a composite score from ten tests and propose to model this score using a partially linear quantile regression model for longitudinal studies with non‐ignorable dropouts. Quantile regression allows for modeling non‐central tendencies. The partially linear model accommodates nonlinear relationships between some of the covariates and cognitive ability. The data set includes patients that leave the study prior to the conclusion. Ignoring such dropouts will result in biased estimates if the probability of dropout depends on the response. To handle this challenge, we propose a weighted quantile regression estimator where the weights are inversely proportional to the estimated probability a subject remains in the study. We prove that this weighted estimator is a consistent and efficient estimator of both linear and nonlinear effects.
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- Award ID(s):
- 1952373
- PAR ID:
- 10543273
- Publisher / Repository:
- Statistics in Medicine
- Date Published:
- Journal Name:
- Statistics in Medicine
- Volume:
- 42
- Issue:
- 16
- ISSN:
- 0277-6715
- Page Range / eLocation ID:
- 2729 to 2745
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1002/sim.9745
