This content will become publicly available on July 1, 2025
- Award ID(s):
- 1809640
- PAR ID:
- 10553133
- Publisher / Repository:
- Elsevier
- Date Published:
- Journal Name:
- Journal of Materials Science & Technology
- Volume:
- 186
- Issue:
- C
- ISSN:
- 1005-0302
- Page Range / eLocation ID:
- 174 to 187
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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Abstract We report a Ni‐catalyzed regioselective α‐carbonylalkylarylation of vinylarenes with α‐halocarbonyl compounds and arylzinc reagents. The reaction works with primary, secondary, and tertiary α‐halocarbonyl molecules, and electronically varied arylzinc reagents. The reaction generates γ,γ‐diarylcarbonyl derivatives with α‐secondary, tertiary, and quaternary carbon centers. The products can be readily converted to aryltetralones, including a precursor to Zoloft, an antidepressant drug.